Lu Zhang
5 Papers
6 Citations
Lu Zhang is an academic researcher. The author has contributed to research in topics: Cancer & Cancer research. The author has an hindex of 4, co-authored 5 publications.
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Papers
Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis
Shujie Chen,Lu Zhang,Mengjie Li,Ying Zhang,Meng Sun,Ling-ling Wang,Jiebo Lin,Yun Emma Cui,Qiang Chen,Chenqi Jin,Xiang Li,Boya Wang,Hao Chen,Tianhua Zhou,Liangjing Wang,Chih-Hung Hsu,Wei Zhuo +16 more
TL;DR: In this paper , the authors reveal that Fusobacterium nucleatum (F. nucleatum) induces a dramatic decline of m6A modifications in colorectal cancer cells and patient-derived xenograft (PDX) tissues by downregulation of METTL3, contributing to inducation of CRC aggressiveness.
Fusobacterium nucleatum promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
Ying Zhang,Lu Zhang,Sheng Zheng,Mengjie Li,Chaochao Xu,Din-Wu Jia,Yadong Qi,Tongyao Hou,Lan Wang,Boya Wang,Aiqing Li,Shujie Chen,Jianmin Si,Wei Zhuo +13 more
TL;DR: A new insight is provided into the role of gut microbiota in engaging into the distant metastasis of CRC cells by inducing a new pattern recognition receptor ALPK1 to activate NF-κB pathway, resulting in the upregulation of ICAM1.
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m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation
Wei Dong Zhuo,Meng Sun,Kun Wang,Lu Zhang,Kai-yu Li,Danyang Yi,Mengjie Li,Qi Sun,Xixi Ma,Wei Liu,Lisong Teng,Chengqi Yi,Tianhua Zhou +12 more
TL;DR: In this article , the authors found that both PCIF1 expression and m 6 Am modification are significantly elevated in gastric cancer tissues, and they also revealed an oncogenic function of PCIF 1.
MAPK4 silencing in gastric cancer drives liver metastasis by positive feedback between cancer cells and macrophages
Shuang Li,Dongyang Guo,Qiang Sun,Lu Zhang,Yun Cui,Min Liu,Xixi Ma,Yiman Liu,Wen-Yu Cui,Leimin Sun,Lisong Teng,Liangjing Wang,Aifu Lin,Wei Li,Wei Dong Zhuo,Tianhua Zhou +15 more
TL;DR: In this paper , a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses is found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis.
m6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation
Wei Dong Zhuo,Meng Sun,Kun Wang,Lu Zhang,Kai Li,Danyang Yi,Mengjie Li,Qiang Sun,Xixi Ma,Wei Li,Lisong Teng,Chengqi Yi,Tianhua Zhou +12 more
TL;DR: In this paper , the authors found that both PCIF1 expression and m 6 Am modification are significantly elevated in gastric cancer tissues, and they also revealed an oncogenic function of PCIF 1.