Lu Yang
4 Papers
Lu Yang is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 2 publications.
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Papers
Single-cell atlases: shared and tissue-specific cell types across human organs
TL;DR: Key biological insights obtained from cross-tissue studies into epithelial, fibroblast, vascular and immune cells based on single-cell gene expression data in humans are highlighted and compared with mechanisms reported in mice.
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Yolk sac cell atlas reveals multiorgan functions during human early development
Issac Goh,Rachel A. Botting,Antony Rose,Simone Webb,Justin Engelbert,Yorick Gitton,Emily Stephenson,Mariana Quiroga Londoño,Michael W. Mather,Nicole Mende,Ivan Imaz-Rosshandler,Lu Yang,Dave Horsfall,Daniela Basurto-Lozada,Nana-Jane Chipampe,Victoria Rook,Jimmy Tsz,H. Lee,Mai-Linh N Ton,Daniel Keitley,Pavel Mazin,Rebecca Hannah,Laure Gambardella,Kile Green,Stephane Ballereau,Megumi Inoue,Elizabeth Tuck,Valentina Lorenzi,Kwasi Kwakwa,Clara Alsinet,Bayanne Olabi,Mohiuddin Miah,Chloe Admane,Dorin Popescu,Meghan Acres,David Dixon,T Ness,Rowen Coulthard,Steven Lisgo,Deborah J. Henderson,Emma Dann,Chenqu Suo,Sarah Kinston,Jong-Eun Park,Krzysztof Polanski,John C. Marioni,S. Dongen,Kerstin B. Meyer,M. D. Bruijn,James Palis,Sam Behjati,Elisa Laurenti,Nicola K. Wilson,Roser Vento-Tormo,Alain Chédotal,Omer Ali Bayraktar,Irene Roberts,Laura Jardine,Berthold Göttgens,Sarah A. Teichmann,Muzlifah Haniffa +60 more
TL;DR: A comprehensive multiomic reference of the extraembryonic yolk sac from 3 to 8 postconception weeks is assembled by integrating single-cell protein and gene expression data and reports that human YS can fuel the accelerated production of macrophages from hematopoietic stem and progenitor cells independently of monocytes.
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Human skeletal muscle aging atlas.
Veronika R. Kedlian,Yaning Wang,Tianliang Liu,Xiaoping Chen,Liam Bolt,Catherine Tudor,Zhuojian Shen,Eirini S. Fasouli,Elena Prigmore,Vitalii Kleshchevnikov,J. Pett,Tong Li,Jean E. Lawrence,Shani Perera,M. Julieta Del Prete,Ni Huang,Qin Guo,Xinrui Zeng,Lu Yang,Krzysztof Polanski,Nana-Jane Chipampe,Monika Dabrowska,Xiaobo Li,Omer Ali Bayraktar,Minal Patel,Natsuhiko Kumasaka,Krishnaa T. Mahbubani,Andy Peng Xiang,Kerstin B. Meyer,Kourosh Saeb-Parsy,Sarah A. Teichmann,Hongbo Zhang +31 more
TL;DR: It is found that distinct subsets of muscle stem cells exhibit decreased ribosome biogenesis genes and increased CCL2 expression, causing different aging phenotypes, causing different aging phenotypes.
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Human skeletal muscle ageing atlas
Veronika R. Kedlian,Yaning Wang,Tianliang Liu,Xiaoping Chen,Liam Bolt,Zhuojian Shen,Eirini S. Fasouli,Elena Prigmore,Vitalii Kleshchevnikov,Tong Li,Jean E. Lawrence,Ni Huang,Qin Guo,Lu Yang,Krzysztof Polanski,Monika Dabrowska,Catherine Tudor,Xiaobo Li,Omer Ali Bayraktar,Minal Patel,Kerstin B. Meyer,Natsuhiko Kumasaka,Krishnaa T. Mahbubani,Andy Peng Xiang,Kourosh Saeb-Parsy,Sarah A. Teichmann,Hongbo Zhang +26 more
TL;DR: A single-cell and single-nucleus transcriptomic atlas of skeletal muscle ageing from 15 donors across the adult human lifespan, accompanied by myofiber typing using imaging is generated, revealing ageing mechanisms acting across different compartments of the muscle, including muscle stem cells, myofibers and the muscle microenvironment.
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