Lu Wang
Chongqing Medical University
11 Papers
40 Citations
Lu Wang is an academic researcher from Chongqing Medical University. The author has contributed to research in topics: Myeloid leukemia & NPM1. The author has an hindex of 7, co-authored 9 publications.
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Papers
Exploration of Serum Exosomal LncRNA TBILA and AGAP2-AS1 as Promising Biomarkers for Diagnosis of Non-Small Cell Lung Cancer.
Yao Tao,Yuting Tang,Zailin Yang,Futao Wu,Lu Wang,Liyuan Yang,Li Lei,Yipei Jing,Xueke Jiang,Hongjun Jin,Yao Bai,Ling Zhang +11 more
TL;DR: The combination of two exosomal lncRNAs and the serum tumor biomarker Cyfra21-1 widely used in clinical practices further improved the diagnostic accuracy for NSCLC patients.
Glycolytic Enzyme PKM2 Mediates Autophagic Activation to Promote Cell Survival in NPM1-Mutated Leukemia
Lu Wang,Liyuan Yang,Zailin Yang,Yuting Tang,Yao Tao,Qian Zhan,Li Lei,Yipei Jing,Xueke Jiang,Hongjun Jin,Qin Zou,Jingrong Xian,Ling Zhang +12 more
TL;DR: It is indicated for the first time that glycolytic enzyme PKM2 mediates autophagic activation and further contributes to cell survival in NPM1-mutated AML, suggesting that PKM 2 may serve as a promising target for treatment of NPM 1-mutation AML.
Up-regulation of EMT-related gene VCAN by NPM1 mutant-driven TGF-β/cPML signalling promotes leukemia cell invasion
Liyuan Yang,Lu Wang,Zailin Yang,Hongjun Jin,Qin Zou,Qian Zhan,Yuting Tang,Yao Tao,Li Lei,Yipei Jing,Xueke Jiang,Ling Zhang +11 more
TL;DR: Findings provide insights into the involvement of EMT-related gene VCAN in the pathogenesis of NPM1-mutated leukemia, which suggests that VCAN is an attractive target for novel diagnostic and therapeutic strategies in N PM1-Mutated AML.
INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia.
Hongjun Jin,Liyuan Yang,Lu Wang,Zailin Yang,Qian Zhan,Yao Tao,Qin Zou,Yuting Tang,Jingrong Xian,Shuaishuai Zhang,Yipei Jing,Ling Zhang +11 more
TL;DR: Inositol polyphosphate 4-phosphatase type II promotes leukemia cell survival via SGK3 activation, and INPP4B might be a potential target in the treatment of NPM1-mutated AML.
Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression.
Shuaishuai Zhang,Fengxian Qin,Liyuan Yang,Jingrong Xian,Qin Zou,Hongjun Jin,Lu Wang,Ling Zhang +7 more
TL;DR: It is found that overexpression of NPM1mA in THP-1 cells sensitized these cells to apoptosis induced by chemotherapeutic agents such as daunorubicin (DNR) and cytarabine (Ara-C).