Lu Sheng
Fudan University
6 Papers
Lu Sheng is an academic researcher from Fudan University. The author has contributed to research in topics: Cell growth & Cancer. The author has an hindex of 5, co-authored 5 publications.
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Papers
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network
Maosheng Cheng,Lu Sheng,Qian Gao,Qiuchan Xiong,Haojie Zhang,Mingqing Wu,Yu Liang,Fengyu Zhu,Yingyin Zhang,Xiuhong Zhang,Quan Yuan,Yang Li +11 more
TL;DR: An AFF4/NF-κB/MYC signaling network operated by METTL3-mediated m6A modification is uncovered and insight into the mechanisms of BCa progression is provided.
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miR-15b-5p facilitates the tumorigenicity by targeting RECK and predicts tumour recurrence in prostate cancer.
TL;DR: Findings indicate that miR‐15b promotes the progression of PCa cells by targeting RECK and represents a potential marker for patients with PCa.
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Low doses of decitabine improve the chemotherapy efficacy against basal-like bladder cancer by targeting cancer stem cells
Mingqing Wu,Lu Sheng,Maosheng Cheng,Haojie Zhang,Yi-Zhou Jiang,Shuibin Lin,Yu Liang,Fengyu Zhu,Zhenqing Liu,Yingyin Zhang,Xiuhong Zhang,Qian Gao,Demeng Chen,Jiong Li,Jiong Li,Yang Li +15 more
TL;DR: Genetic lineage tracing revealed that the stemness of a bladder cancer stem cell population was inhibited by decitabine treatment in mice, indicating that this DNA-demethylating reagent is a promising therapeutic approach for basal-like bladder cancer treatment.
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RETRACTED: Twist2 promotes kidney cancer cell proliferation and invasion via regulating ITGA6 and CD44 expression in the ECM-Receptor-Interaction pathway
TL;DR: It is shown that Twist2 up-regulated in human kidney cancer tissues compared with normal kidney tissues, and knockdown of Twist2 decreased the levels of ITGA6 and CD44 which contribute to cell migration and invasion correlated with ECM-Receptor-Interaction pathway, which indicates Twist2 may promote Migration and invasion of kidney cancer cells by regulating ITGA 6 andCD44 expression.
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Exosome-Mediated miR-4792 Transfer Promotes Bladder Cancer Cell Proliferation via Enhanced FOXC1/c-Myc Signaling and Warburg Effect
TL;DR: These findings provided the first evidence that the exosome-mediated delivery of miR-4792 could play an important role in bladder cancer development through the downregulation of FOXC1 and c-Myc, which further inhibited aerobic glycolysis and lactic acid content.