28 Papers
110 Citations
Lu Lu is an academic researcher from Li Ka Shing Faculty of Medicine, University of Hong Kong. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 11 publications.
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Papers
Pathogenicity, transmissibility, and fitness of SARS-CoV-2 Omicron in Syrian hamsters
Shuofeng Yuan,Zi Ye,Ronghui Liang,Kaiming Tang,Anna Jinxia Zhang,Gang Liu,Chon Phin Ong,Vincent Kwok Man Poon,Chris Chung-Sing Chan,Bobo Wing-Yee Mok,Zhen Qin,Yubin Xie,Allen Wing-Ho Chu,Wan-Mui Chan,Jonathan Daniel Ip,Hao Sun,Jessica Oi-Ling Tsang,Terrence Tsz-Tai Yuen,Kenn Ka-Heng Chik,Chris Chun-Yiu Chan,Jian Piao Cai,Cuiting Luo,Lu Lu,Cyril C. Y. Yip,Hin Chu,Kelvin K. W. To,Honglin Chen Chen,Dong-Yan Jin,Kwok-Yung Yuen,Jasper Fuk-Woo Chan +29 more
TL;DR: In non-contact transmission studies, Omicron demonstrated similar or higher transmissibility than Delta, but this scenario drastically changed once immune selection pressure with neutralizing antibodies active against Delta but poorly active against Omicrons was introduced.
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Emerging SARS-CoV-2 variants expand species tropism to murines.
Huiping Shuai,Jasper Fuk-Woo Chan,Terrence Tsz-Tai Yuen,Chaemin Yoon,Jingchu Hu,Lei Wen,Bingjie Hu,Dong Yang,Yixin Wang,Yuxin Hou,Xiner Huang,Yue Chai,Chris Chung-Sing Chan,Vincent Kwok-Man Poon,Lu Lu,Rui-Qi Zhang,Wan-Mui Chan,Jonathan Daniel Ip,Allen Wing-Ho Chu,Y.F. Hu,Jian-Piao Cai,Kwok-Hung Chan,Jie Zhou,Siddharth Sridhar,Baozhong Zhang,Shuofeng Yuan,Anna Jinxia Zhang,Jian-Dong Huang,Jian-Dong Huang,Kelvin K. W. To,Kwok-Yung Yuen,Hin Chu +31 more
TL;DR: The results reveal that the current predominant circulating SARS-CoV-2 variant, B.1.1-inocluated mice and rats, has gained the capability to expand species tropism to rodents.
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Additional molecular testing of saliva specimens improves the detection of respiratory viruses
Kelvin K. W. To,Lu Lu,Cyril C. Y. Yip,Rosana Ws Poon,Ami M. Y. Fung,Andrew Kai-Chun Cheng,Daniel Hk Lui,Deborah Ty Ho,Ivan Fn Hung,Kwok-Hung Chan,Kwok-Yung Yuen +10 more
TL;DR: Although NPAs have high viral loads and remain the specimen of choice for most patients with respiratory virus infections, supplementary molecular testing of saliva can improve the clinical management of these patients.
Seroprevalence of SARS-CoV-2 in Hong Kong and in residents evacuated from Hubei province, China: a multicohort study
Kelvin K. W. To,Vincent C.C. Cheng,Jian-Piao Cai,Kwok-Hung Chan,Lin-Lei Chen,Lok-Hin Wong,Charlotte Yee Ki Choi,Carol Ho-Yan Fong,Anthony Chin-Ki Ng,Lu Lu,Cuiting Luo,Jianwen Situ,Tom Wai-Hin Chung,Shuk-Ching Wong,Grace See-Wai Kwan,Siddharth Sridhar,Jasper Fuk-Woo Chan,Cecilia Yuen-Man Fan,Vivien W M Chuang,Kin-Hang Kok,Ivan Hung,Kwok-Yung Yuen +21 more
- 01 Jul 2020
TL;DR: The serological data suggest that SARS-CoV-2 is a new emerging virus, and the low seroprevalence suggests that most of the Hong Kong and Hubei population remain susceptible to COVID-19.
Omicron variant susceptibility to neutralizing antibodies induced in children by natural SARS-CoV-2 infection or COVID-19 vaccine
Lin-Lei Chen,Gilbert T. Chua,Lu Lu,Brian Chun-Yuan Chan,Joshua S C Wong,Calvin Chit Kwong Chow,Tak-Ching Yu,Agnes Sze Yin Leung,Shu Yan Lam,Tak Wai Wong,Hing Wai Tsang,Ian C. K. Wong,Kwok-Hung Chan,Kwok-Yung Yuen,Patricia Ip,Mike Y W Kwan,Kelvin K. W. To +16 more
TL;DR: The results suggest that vaccine recipients and COVID-19 patients in the pediatric age group will likely be more susceptible to vaccine breakthrough infections or reinfections due to the Omicron variant than previous variants.
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