Lu Liu
5 Papers
2 Citations
Lu Liu is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
Perfluorooctanoic acid (PFOA) exposure affects early embryonic development and offspring oocyte quality via inducing mitochondrial dysfunction.
TL;DR: Wang et al. as mentioned in this paper found that PFOA exposure in vitro disrupted spindle assembly and chromosome alignment during the first cleavage of early mouse embryos, which impacted early embryonic cleavage and blastocyst formation.
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Exposure to phenanthrene affects oocyte meiosis by inducing mitochondrial dysfunction and endoplasmic reticulum stress
TL;DR: It is demonstrated that mitochondrial dysfunction and ER stress-induced oxidative stress and DNA damage are the major cause of poor oocyte quality after PHE exposure.
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Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function.
TL;DR: In this paper , the pineal gland synthesized by pineal glands has been shown to have beneficial effects on oocyte quality owing to its antioxidative function, and the exposure of oocytes of diabetic mice to melatonin, in vitro , alleviated aberrant oocyte maturation competence.
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Validation of reliable safe harbor locus for efficient porcine transgenesis
Xiang Ma,Weijun Zeng,Lei Wang,Rui Cheng,Cai Lan Jennifer Huang,Zhongxin Sun,Peipei Tao,Tao Wang,Jufang Zhang,Lu Liu,Xing Duan,Dong Niu +11 more
TL;DR: It was found that transgenesis could relatively alter the expression of the adjacent endogenous genes, but the influence was limited, and the COL1A1 and ROSA26 loci were confirmed to be the best two SH loci with the COL 1A1 being more competitive for porcine transGenesis.
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Disrupting endogenous retroelements with a reverse transcriptase inhibitor alleviates DSS-induced colitis in mice
Yifan Niu,Yu Liu,Xiang Ma,Lu Liu,Sihong Li,Rui Li,Tao Wang,Houhui Song,Dong Niu +8 more
TL;DR: A reverse transcriptase inhibitor, azidothymidine (AZT), alleviates DSS-induced colitis in mice by inhibiting endogenous retroelement expression, downregulating the cGAS/STING/NF-κB pathway, and blocking M1 macrophage polarization, suggesting a new therapeutic strategy for colitis.