Lu Liu
Fudan University
10 Papers
43 Citations
Lu Liu is an academic researcher from Fudan University. The author has contributed to research in topics: Antibody & Immunology. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Lu Liu include Fudan University Shanghai Medical College.
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Papers
Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease.
Zhongfang Wang,Zhongfang Wang,Lingyan Zhu,Thi H. O. Nguyen,Yanmin Wan,Sneha Sant,Sergio M. Quiñones-Parra,Jeremy Chase Crawford,Auda A. Eltahla,Simone Rizzetto,Rowena A. Bull,Chenli Qiu,Marios Koutsakos,E. Bridie Clemens,Liyen Loh,Tianyue Chen,Lu Liu,Pengxing Cao,Yanqin Ren,Lukasz Kedzierski,Tom Kotsimbos,James M. McCaw,Nicole L. La Gruta,Nicole L. La Gruta,Stephen J. Turner,Stephen J. Turner,Allen C. Cheng,Fabio Luciani,Xiaoyan Zhang,Peter C. Doherty,Peter C. Doherty,Paul G. Thomas,Jianqing Xu,Katherine Kedzierska,Katherine Kedzierska +34 more
TL;DR: Molecular and phenotypic analysis is used to establish persistence of clonally diverse CD8+ T cell populations during fatal infection and proposes that effective expansion of cross-reactive influenza-specific TCRαβ clonotypes with appropriate transcriptome signatures is needed for early protection against severe influenza disease.
Drug susceptibility profile and pathogenicity of H7N9 influenza virus (Anhui1 lineage) with R292K substitution
Xiaonan Zhang,Zhigang Song,Jing He,Hui-Ling Yen,Jianhua Li,Zhaoqin Zhu,Di Tian,Wei Wang,Lei Xu,Wencai Guan,Yi Liu,Sen Wang,Bisheng Shi,Wanju Zhang,Boyin Qin,Jialin Cai,Yanmin Wan,Chunhua Xu,Xiaonan Ren,Haili Chen,Lu Liu,Yuqin Yang,Xiaohui Zhou,Wenjiang Zhou,Jianqing Xu,Xiaoyan Zhang,Malik Peiris,Yunwen Hu,Zhenghong Yuan +28 more
TL;DR: This study suggested non-NAIs should be tested clinically for H7N9 patients with a sustained high viral load and possible drug combination regimens, such as T-705 plus ribavirin, should be further tested in animal models.
Induction of Broadly Cross-Reactive Stalk-Specific Antibody Responses to Influenza Group 1 and Group 2 Hemagglutinins by Natural H7N9 Virus Infection in Humans
Lu Liu,Raffael Nachbagauer,Lingyan Zhu,Yang Huang,Xinci Xie,Shan Jin,Anli Zhang,Yanmin Wan,Ariana Hirsh,Di Tian,Xiaolin Shi,Zhaoguang Dong,Songhua Yuan,Yunwen Hu,Florian Krammer,Xiaoyan Zhang,Jianqing Xu +16 more
TL;DR: The results indicate that cross-group binding and neutralizing antibody responses primarily targeting the stalk region can be elicited after natural influenza virus infection.
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Differential compartmentalization of HIV-targeting immune cells in inner and outer foreskin tissue.
TL;DR: The present study is the first to employ both CCR5 and α4β7 to identify HIV target cells in the foreskin, and this data suggests the R5-tropism of HIV sexual transmission is likely shaped through the inherent receptor composition on HIV target Cells in the mucosa.
Influenza Vaccine With Consensus Internal Antigens as Immunogens Provides Cross-Group Protection Against Influenza A Viruses.
Xinci Xie,Chen Zhao,Qian He,Tianyi Qiu,Songhua Yuan,Longfei Ding,Lu Liu,Lang Jiang,Jing Wang,Linxia Zhang,Chao Zhang,Xiang Wang,Dongming Zhou,Xiaoyan Zhang,Jianqing Xu +14 more
TL;DR: By targeting highly conserved internal viral epitopes to efficiently generate both respiratory and systemic memory T cells, the sequential vaccination strategy reported here represented a new promising candidate for the development of T-cell based universal influenza vaccines.