32 Papers
53 Citations
Lu Liu is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: AMPK & Internal medicine. The author has an hindex of 13, co-authored 28 publications.
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Papers
Activation of AMPK inhibits TGF-β1-induced airway smooth muscle cells proliferation and its potential mechanisms
Yilin Pan,Lu Liu,Shaojun Li,Ke Wang,Rui Ke,Wenhua Shi,Jian Wang,Xin Yan,Qianqian Zhang,Qingting Wang,Limin Chai,Xinming Xie,Manxiang Li +12 more
TL;DR: The study suggests that activation of AMPK modulates miR-206/HDAC4/cyclin D1 signaling pathway, particularly targeting on HDAC4, to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by alleviating airway remodeling.
Activation of AMPK inhibits pulmonary arterial smooth muscle cells proliferation.
Yuanyuan Wu,Lu Liu,Yonghong Zhang,Guizuo Wang,Dong Han,Rui Ke,Shaojun Li,Wei Feng,Manxiang Li +8 more
TL;DR: The study suggests that activation of AMPK suppresses PASMCs proliferation and has potential value in negatively modulating pulmonary vascular remodeling and therefore could prevent or treat the development of pulmonary arterial hypertension (PAH).
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Activation of AMPK Prevents Monocrotaline-Induced Extracellular Matrix Remodeling of Pulmonary Artery.
Shaojun Li,Dong Han,Yonghong Zhang,Xinming Xie,Rui Ke,Yanting Zhu,Lu Liu,Yang Song,Lan Yang,Manxiang Li +9 more
TL;DR: This study suggests that activation of AMPK benefits PAH by inhibiting ECM remodeling of pulmonary arteries and Enhancing AMPK activity might have potential value in clinical treatment of PAH.
Activation of AMPK α2 inhibits airway smooth muscle cells proliferation.
TL;DR: The study suggests that activation of AMPK, particularly AMPK α2, negatively regulates mTOR activity to suppress ASMCs proliferation and therefore has a potential value in the prevention and treatment of asthma by negatively modulating airway remodeling.
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SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms.
Jian Wang,Wei Feng,Fangwei Li,Wenhua Shi,Cui Zhai,Shaojun Li,Yanting Zhu,Xin Yan,Qingting Wang,Lu Liu,Xinming Xie,Manxiang Li +11 more
TL;DR: This study indicates that Smad2/3/SphK1/S1P/Notch3 pathway mediates TGF-β1-induced PASMC proliferation and suggests this pathway as a potential therapeutic target in the prevention and treatment of pulmonary hypertension.
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