Lu Li
4 Papers
Lu Li is an academic researcher. The author has contributed to research in topics: Methylation & Medicine. The author has an hindex of 1, co-authored 2 publications.
Chat about Author
Papers
FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke
Bin Li,Wen Xi,Ying Bai,Xueyu Liu,Yuan Zhang,Lu Li,Liang Bian,Chenchen Liu,Ying Tang,Ling Shen,Li Yang,Xiaochun Gu,Jian Xie,Zhongqiu Zhou,Yu Ning Wang,Jianhong Wang,Jie Chao,Bing Han,Honghong Yao +18 more
TL;DR: In this paper , the role of Circular RNA SCMH1 (circSCMH1) in promoting vascular repair in peri-infarct cortex of male mice and male monkeys after photothrombotic (PT) stroke, and attenuating the ischemia-induced m6A methylation in male mice after PT stroke.
Integrating spatial and single-cell transcriptomics to characterize the molecular and cellular architecture of the ischemic mouse brain
Bing Han,Shunheng Zhou,Yuan Zhang,Sina Chen,Wen Xi,Chenchen Liu,Xu Zhou,Mengqin Yuan,Xiaoyu Yu,Lu Li,Yu Wang,Hui Ren,Jian Xie,Bin Li,Minzi Ju,You Zhou,Ziqi Liu,Zhongli Xiong,Ling Shen,Ying Bai,Jun Chen,Wei Jiang,Honghong Yao +22 more
TL;DR: This study provides a detailed molecular and cellular characterization of the peri-infact area in a murine stroke model and revealed Lgals9 as potential treatment target that warrants further investigation, highlighting the utility of integrating single-cell and spatial transcriptomics to characterize cellular changes in disease states and to identify potential therapeutic targets.
26
Mutual regulation of noncoding RNAs and RNA modifications in psychopathology: Potential therapeutic targets for psychiatric disorders?
Bing Han,Wen Li Xi,Yiting Hong,Liyuan Gu,Yue Chao,Lu Li,Chenchen Liu,Li Yang,Jie Chao,Honghong Yao +9 more
TL;DR: The human brain is specifically enriched for multiple classes of noncoding RNAs (ncRNAs) and for particular RNA modifications, both of which are increasingly recognized to contribute to the etiology and pathophysiology of psychiatric disorders as mentioned in this paper .
2
Inhibition of OGFOD1 by FG4592 confers neuroprotection by activating unfolded protein response and autophagy after ischemic stroke
Jian Xie,Yuan Zhang,Wen Xi,Yu Wang,Lu Li,Bing Han,Yan Kong,Honghong Yao,Zhijun Zhang +8 more
TL;DR: FG4592, a PHD inhibitor, confers neuroprotection after ischemic stroke by inhibiting OGFOD1, activating unfolded protein response and autophagy, and inhibiting apoptosis, suggesting a novel therapeutic target for ischemic stroke treatment.
1