6 Papers
Lu Jiang is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: microRNA & Gene knockdown. The author has an hindex of 6, co-authored 6 publications.
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Papers
MicroRNA-138 suppresses invasion and promotes apoptosis in head and neck squamous cell carcinoma cell lines
TL;DR: Results suggested miR-138 acts as a tumor suppresser and may serve as a therapeutic target for HNSCC patients at risk of metastasis.
214
•Journal Article
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines.
TL;DR: The results indicate that hsa-miR-222 plays an important role in OTSCC invasion, and may serve as a novel therapeutic target for O TSCC patients at risk of metastatic disease.
168
MicroRNA-24 targeting RNA-binding protein DND1 in tongue squamous cell carcinoma
Xiqiang Liu,Anxun Wang,Anxun Wang,Caroline E. Heidbreder,Lu Jiang,Jinsheng Yu,Antonia Kolokythas,Lei Huang,Yang Dai,Xiaofeng Zhou +9 more
TL;DR: The up‐regulation of miR‐24 in TSCC reduced the expression of RNA‐binding protein dead end 1 (DND1) and suppression of cyclin‐dependent kinase inhibitor 1B (CDKN1B) and led to enhanced proliferation and reduced apoptosis in TS CC cells.
88
Downregulation of the Rho GTPase signaling pathway is involved in the microRNA-138-mediated inhibition of cell migration and invasion in tongue squamous cell carcinoma.
Lu Jiang,Xiqiang Liu,Xiqiang Liu,Antonia Kolokythas,Jinsheng Yu,Anxun Wang,Anxun Wang,Caroline E. Heidbreder,Fei Shi,Xiaofeng Zhou +9 more
TL;DR: The results suggest that miR‐138 plays an important role in TSCC cell migration and invasion by concurrently targeting RhoC and ROCK2, and miR-138 may serve as a novel therapeutic target for TSCC patients at risk of metastatic disease.
Identification and experimental validation of G protein alpha inhibiting activity polypeptide 2 (GNAI2) as a microRNA-138 target in tongue squamous cell carcinoma
Lu Jiang,Yang Dai,Xiqiang Liu,Cheng Wang,Anxun Wang,Anxun Wang,Zujian Chen,Caroline E. Heidbreder,Antonia Kolokythas,Xiaofeng Zhou +9 more
TL;DR: A number of high-confident miR-138 target genes are identified, including proto-oncogene GNAI2, which may play an important role in TSCC initiation and progression.