6 Papers
Lu He is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Apoptosis & Cell growth. The author has an hindex of 5, co-authored 6 publications.
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Papers
ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
Chuangyu Wen,Huihui Wang,Xiaobin Wu,Lu He,Qian Zhou,Fang Wang,Siyu Chen,Lanlan Huang,Junxiong Chen,Huashe Wang,Weibiao Ye,Wende Li,Xiangling Yang,Huanliang Liu,Junsheng Peng +14 more
TL;DR: It is revealed that chaetocin induces the excessive accumulation of ROS via inhibition of TRXR-1, followed by PI3K/AKT pathway inactivation, which ultimately inhibits proliferation and induces caspase-dependent apoptosis in GC cells.
ROS/JNK/c-Jun axis is involved in oridonin-induced caspase-dependent apoptosis in human colorectal cancer cells
TL;DR: Oridonin induces apoptosis through the ROS/JNK/c-Jun axis in both 5-FU sensitive and resistant CRC cells, suggesting that oridonin could be a potential agent for CRC treatment.
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Pseudolaric acid B induces mitotic arrest and apoptosis in both 5-fluorouracil-sensitive and -resistant colorectal cancer cells
Chuangyu Wen,Junxiong Chen,Di Zhang,Huihui Wang,Jia Che,Qiyuan Qin,Lu He,Zerong Cai,Mengmeng Lin,Qiong Lou,Lanlan Huang,Daici Chen,Aikichi Iwamoto,Donglin Ren,Lei Wang,Ping Lan,Jianping Wang,Huanliang Liu,Xiangling Yang +18 more
TL;DR: Data reveal that PAB induces CRC cell mitotic arrest followed by apoptosis and overcomes 5-FU resistance in vitro and in-vivo, suggesting that P AB may be a potential agent for CRC treatment, particularly for 5-fu-resistant CRC.
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Toosendanin-induced apoptosis in colorectal cancer cells is associated with the κ-opioid receptor/β-catenin signaling axis.
Huihui Wang,Chuangyu Wen,Siyu Chen,Fang Wang,Lu He,Weiqian Li,Qian Zhou,Wai Kin Yu,Lanlan Huang,Junxiong Chen,Liu Ruixian,Wende Li,Xiangling Yang,Huanliang Liu +13 more
TL;DR: The data demonstrate that TSN-induced apoptosis in CRC cells is associated with the κ-opioid receptor/β-catenin signaling axis, and TSN has promising potential as an antitumor agent for CRC treatment.
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Reduced-gliotoxin induces ROS-mediated anoikis in human colorectal cancer cells
Junxiong Chen,Qiong Lou,Lu He,Chuangyu Wen,Mengmeng Lin,Zefeng Zhu,Fang Wang,Lanlan Huang,Wen-Jian Lan,Aikichi Iwamoto,Xiangling Yang,Huanliang Liu +11 more
TL;DR: Results suggest that reduced-gliotoxin may prove to be a potential candidate in the treatment of CRC, after demonstrating that it triggered rapid cell detachment and induced anoikis in CRC cells.