Lu E. Jin
Yale University
13 Papers
1 Citations
Lu E. Jin is an academic researcher from Yale University. The author has contributed to research in topics: Working memory & Prefrontal cortex. The author has an hindex of 11, co-authored 13 publications.
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Papers
Neuronal basis of age-related working memory decline
Min Wang,Nao J. Gamo,Yang Yang,Lu E. Jin,Xiao Jing Wang,Mark Laubach,James A. Mazer,Daeyeol Lee,Amy F.T. Arnsten +8 more
TL;DR: The cellular basis of age-related cognitive decline in dorsolateral PFC is revealed, and physiological integrity can be rescued by addressing the molecular needs of PFC circuits, and is demonstrated by restoring an optimal neurochemical environment.
NMDA Receptors Subserve Persistent Neuronal Firing during Working Memory in Dorsolateral Prefrontal Cortex
Min Wang,Yang Yang,Ching Jung Wang,Nao J. Gamo,Lu E. Jin,James A. Mazer,John H. Morrison,Xiao Jing Wang,Xiao Jing Wang,Amy F.T. Arnsten +9 more
TL;DR: Examining glutamate receptor influences underlying persistent firing in primate dlPFC during a spatial working memory task found many Response cells were sensitive to AMPAR blockade and increased firing after systemic ketamine, indicating that models of ketamine actions should be refined to reflect neuronal heterogeneity.
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Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
TL;DR: It is shown that α7-nAChR stimulation is needed for NMDA actions, suggesting that it is key for the engagement of dlPFC circuits, and this findings may explain how ACh shapes differing mental states during wakefulness vs. sleep.
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cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex
Becky C. Carlyle,Angus C. Nairn,Min Wang,Yang Yang,Lu E. Jin,Arthur A. Simen,Brian P. Ramos,Kelly A. Bordner,George E. Craft,Peter Davies,Mihovil Pletikos,Nenad Sestan,Amy F.T. Arnsten,Constantinos D. Paspalas +13 more
TL;DR: Age-related increase in cAMP-dependent protein kinase (PKA) phosphorylation of tau at serine 214 (pS214-tau) in monkey dorsolateral prefrontal association cortex (dlPFC), which specifically targets spine synapses and the Ca2+-storing spine apparatus is revealed.
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mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks.
Lu E. Jin,Min Wang,Veronica C. Galvin,Taber C. Lightbourne,P.J. Conn,Amy F.T. Arnsten,Constantinos D. Paspalas +6 more
TL;DR: It is discovered that, in addition to their astrocytic expression, mGluR3 is concentrated postsynaptically in spine synapses of layer III dlPFC, positioned to strengthen connectivity by inhibiting postsynaptic cAMP-K+ channel actions, and supported as a novel therapeutic target for higher cognitive disorders.
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