Lu Ding
Boston Children's Hospital
18 Papers
32 Citations
Lu Ding is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Male infertility & Intracytoplasmic sperm injection. The author has an hindex of 11, co-authored 18 publications.
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Papers
TSGA10 is a novel candidate gene associated with acephalic spermatozoa.
Yanwei Sha,Yan-Kun Sha,Zhi-Yong Ji,Libin Mei,Lu Ding,Qing Zhang,Ping-Ping Qiu,Shaobin Lin,Xu Wang,Ping Li,Xiaohui Xu,Lin Li +11 more
TL;DR: A 27 years old infertile male from a consanguineous family, who presented with 99% headless sperm in his ejaculate is reported, suggesting the presence of rare sequence variants within TSGA10 may be associated with acephalic spermatozoa in humans.
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DNAH2 is a novel candidate gene associated with multiple morphological abnormalities of the sperm flagella
Yang Li,Yanwei Sha,Xiong Wang,Lu Ding,Wensheng Liu,Zhi-Yong Ji,Libin Mei,Xianjing Huang,Shaobin Lin,Shuangbo Kong,Jinhua Lu,Weibing Qin,Xinzhong Zhang,Jianmin Zhuang,Yunge Tang,Zhongxian Lu +15 more
TL;DR: The data suggest that the DNAH2 mutation can cause severe sperm flagella defects that damage sperm motility, and provides a novel genetic pathogeny for the human MMAF phenotype.
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Loss-of-function mutations in SPEF2 cause multiple morphological abnormalities of the sperm flagella (MMAF)
Wensheng Liu,Yanwei Sha,Yang Li,Libin Mei,Shaobin Lin,Xianjing Huang,Jinhua Lu,Lu Ding,Shuangbo Kong,Zhongxian Lu +9 more
TL;DR: It is indicated that loss-of-function mutations in the SPEF2 gene can cause the MMAF phenotype in human, a kind of severe teratozoospermia.
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A novel TEX11 mutation induces azoospermia: a case report of infertile brothers and literature review
Yanwei Sha,Liang-Kai Zheng,Zhi-Yong Ji,Libin Mei,Lu Ding,Shaobin Lin,Xu Wang,Xiaoyu Yang,Ping Li +8 more
TL;DR: This study and previous literature indicate that TEX11 mutations are closely associated with male infertility, especially azoospermia, although auxiliary clinical analyses are needed to figure out the causes of male infertility.
Biallelic mutations in PMFBP1 cause acephalic spermatozoa.
Yanwei Sha,Xiong Wang,Xiaohui Xu,Lu Ding,Wensheng Liu,Ping Li,Zhi-Ying Su,Jing Chen,Libin Mei,Liang-Kai Zheng,Hai-Long Wang,Shuangbo Kong,Min You,Jian-Feng Wu +13 more
TL;DR: It is indicated that PMFBP1 is necessary for sperm morphology in both humans and mice, and that biallelic truncating mutations in PMF BP1 cause acephalic spermatozoa.
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