7 Papers
144 Citations
Lu Deng is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 5, co-authored 7 publications.
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Papers
Structural evidence for a bifurcated mode of action in the antibody-mediated neutralization of hepatitis C virus
Lu Deng,Lilin Zhong,Evi Struble,Hongying Duan,Li Ma,Christine Harman,Hailing Yan,Maria Luisa Virata-Theimer,Zhong Zhao,Stephen M. Feinstone,Harvey J. Alter,Pei Zhang +11 more
TL;DR: Structural insights into the key determinants for the antibody-mediated neutralization may contribute to the immune prophylaxis of HCV infection and the development of an effective HCV vaccine.
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Discrete conformations of epitope II on the hepatitis C virus E2 protein for antibody-mediated neutralization and nonneutralization.
Lu Deng,Li Ma,Maria Luisa Virata-Theimer,Lilin Zhong,Hailing Yan,Zhong Zhao,Evi Struble,Stephen Feinstone,Harvey J. Alter,Pei Zhang +9 more
TL;DR: X-ray crystallographic analysis revealed that one of the critical antibody-binding sites on the hepatitis C virus exists in different shapes and is governed by a highly conserved glycine residue that serves as a flexible joint connecting the two essential parts of the binding site.
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Amino Acid Residue-Specific Neutralization and Nonneutralization of Hepatitis C Virus by Monoclonal Antibodies to the E2 Protein
Hongying Duan,A. V. Kachko,Lilin Zhong,Evi Struble,Shivani Pandey,Hailing Yan,Christine Harman,Maria Luisa Virata-Theimer,Lu Deng,Zhong Zhao,Marian E. Major,Stephen M. Feinstone,Pei Zhang +12 more
TL;DR: The data suggest that the effectiveness of antibody-mediated neutralization of HCV could be deduced from the interplay between an antibody and a specific set of amino acid residues, which should provide insights for designing a vaccine to control HCV infection in vivo.
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A neutralization epitope in the hepatitis C virus E2 glycoprotein interacts with host entry factor CD81.
Zhong Zhao,Lilin Zhong,Elizabeth Elrod,Evi Struble,Li Ma,Hailing Yan,Christine Harman,Lu Deng,Maria Luisa Virata-Theimer,Peter Liu,Harvey J. Alter,Arash Grakoui,Pei Zhang +12 more
TL;DR: It is demonstrated here that 1H8 recognized an epitope mapped between residues A524 and W529 of the E2 protein that neutralizes HCV in vitro, and the characterization of this neutralization epitope with a function in host entry factor CD81 interaction should enhance the understanding of antibody-mediated neutralization of HCV infections.
Multiple Epitopes of Hepatitis B Virus Surface Antigen Targeted by Human Plasma-derived Immunoglobulins Coincide with Clinically Observed Escape Mutations
Sreya Tarafdar,Maria Luisa Virata,Hailing Yan,Lilin Zhong,Lu Deng,Yanqun Xu,Yong He,Evi Struble,Pei Zhang +8 more
TL;DR: In this article, the authors identified five clusters of peptides that corresponded to five distinct anti-HBs binding sites on the hepatitis B surface antigen (HBsAg) and tested in binding assays HBsAg peptides containing clinically relevant mutations previously reported within these sites, such as Y134S, P142S and G145R, and observed a significant reduction in antibody binding activity to the mutated sites.
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