Lu Chen
Nanjing University
8 Papers
1 Citations
Lu Chen is an academic researcher from Nanjing University. The author has contributed to research in topics: Cancer cell & Embryonic stem cell. The author has an hindex of 3, co-authored 6 publications.
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Papers
Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells.
Zan Zhang,Anhua Lei,Liyang Xu,Lu Chen,Yonglong Chen,Xuena Zhang,Yan Gao,Xiaoli Yang,Min Zhang,Ying Cao +9 more
TL;DR: It is shown that inhibition of the epigenetic modification enzyme enhancer of zeste homolog 2 (EZH2), histone deacetylases 1 and 3, lysine demethylase 1A (LSD1), or DNA methyltransferase 1 (DNMT1), which all promote cancer development and progression, leads to postmitotic neuron-like differentiation with loss of malignant features in distinct solid cancer cell lines.
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Coordinated regulation of the ribosome and proteasome by PRMT1 in the maintenance of neural stemness in cancer cells and neural stem cells
TL;DR: This paper showed that loss of neural stemness in cancer or neural stem cells via muscle-like differentiation or neuronal differentiation, respectively, caused downregulation of ribosome and proteasome components and major epigenetic factors, including PRMT1, EZH2, and LSD1.
12
Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease
Xiaolian Ye,Lu Chen,He Wang,Shixiao Peng,Mengjia Liu,Liyan Yao,Yi-Zhi Zhang,Yun Shi,Ying Cao,Jian-Jun Yang,Guiquan Chen +10 more
TL;DR: Neuron-specific deletion of PDK1 robustly ameliorates AD-like pathology and improves spatial working memory in 5×FAD mice and it is proposed that genetic approach to inhibitPDK1 may be an effective strategy to slow AD.
4
Estimation of Patient Out of Pocket Cost for Radiation Therapy by Insurance Type and Treatment Modality.
Lu Chen,Ying Cao,K. D'Rummo,Xinglei Shen +3 more
TL;DR: In this article , a multivariable logistic regression was used to examine associations between insurance factors, radiation technique, concurrent systemic therapy, and month of treatment with a patient reaching OOP maximum with radiation treatment.
2
Coordinated regulation of ribosomes and proteasomes by PRMT1 in the maintenance of neural stemness of cancer cells and neural stem cells
TL;DR: It is shown that loss of neural stemness in cancer cells or neural stem cells leads to simultaneous down regulation of components of ribosomes and proteasomes, which are responsible for protein synthesis and degradation, respectively, and downregulation of major epigenetic factors.