Lu Cai
7 Papers
Lu Cai is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 5 publications.
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Papers
Nrf2 transcriptional upregulation of IDH2 to tune mitochondrial dynamics and rescue angiogenic function of diabetic EPCs
Xiaozhen Dai,Kai Wang,Jiawei Fan,Hanjie Liu,Xiao-Bao Fan,Qian Lin,Yuhong Chen,Hu Chen,Youming Li,Hairong Liu,Oscar Chen,Jing Chen,Xiaohong Li,Di Ren,Ji Sai Li,Daniel J. Conklin,Kupper A. Wintergerst,Yu Li,Lu Cai,Zhongbin Deng,Xiaojing Yan,Yi Tan +21 more
TL;DR: In this paper , the expression of Nrf2 and its downstream genes were decreased in EPCs from both diabetic patients and db/db mice, and the survival ability and angiogenic function were impaired.
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Diabetic cardiomyopathy - Zinc preventive and therapeutic potentials by its anti-oxidative stress and sensitizing insulin signaling pathways.
TL;DR: Pre-clinical and clinical evidence is provided for the preventive and therapeutic potential of zinc supplementation through its anti-oxidative stress and sensitizing insulin signaling actions and the role of zinc homeostasis in insulin signaling pathways.
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Sulforaphane Does Not Protect Right Ventricular Systolic and Diastolic Functions in Nrf2 Knockout Pulmonary Artery Hypertension Mice
Guangyan Zhang,Yin Kang,Dakotah Cathey,Amanda J. LeBlanc,Jun Cai,Lu Cai,Sheng Wang,Jiapeng Huang,Bradley B. Keller +8 more
TL;DR: In this article , Nrf2 dependence for SFN-mediated prevention of pulmonary arterial hypertension (PAH) and right ventricular (RV) dysfunction was investigated in an NRF2 knockout mouse model.
FGF1ΔHBS delays the progression of diabetic nephropathy in late-stage type 2 diabetes mouse model by alleviating renal inflammation, fibrosis, and apoptosis.
Qian Lin,Oscar Chen,John P. Wise,Hongxue Shi,Kupper A. Wintergerst,Lu Cai,Yi Tan +6 more
TL;DR: A non-mitogenic variant of fibroblast growth factor 1 (FGF1ΔHBS) was demonstrated to prevent diabetic nephropathy in an early-stage (2-month-old) type 2 diabetes (T2D) mouse model as discussed by the authors .
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Diabetic Cardiomyopathy and Cell Death: Focus on Metal-Mediated Cell Death.
Lu Cai,Yi Tan,Brian Holland,Kupper A. Wintergerst +3 more
TL;DR: The intent of the review is to further stimulate work in the field to advance the body of knowledge and continue to drive efforts to develop more advanced therapeutic approaches to prevent cell death, particularly metal-dependent cell death, and, ultimately, to reduce or prevent the development of DCM.
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