Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes
TL;DR: It is suggested that monocytes shift from intercellular communication to basic innate defensive functions in response to zinc deficiency, and the use of CHELEX-treated medium strongly augmented cytokine production, independently from its capability for zinc removal.
Cellular zinc homeostasis is a regulator in monocyte differentiation of HL-60 cells by 1α,25-dihydroxyvitamin D3
TL;DR: A model in which the intracellular‐free zinc concentration limits AC activity, and the decrease of zinc after 1,25D3 treatment promotes differentiation by relieving AC inhibition is suggested, suggesting cellular zinc homeostasis acts as an endogenous modulator of monocyte differentiation.
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Polymorphonuclear leucocytes selectively produce anti-inflammatory interleukin-1 receptor antagonist and chemokines, but fail to produce pro-inflammatory mediators.
Anja K. Schröder,Maren von der Ohe,Ute Kolling,Julia Altstaedt,Peter Uciechowski,Daniela Fleischer,Klaus Dalhoff,Xin-Sheng Ju,Martin Zenke,Nicole Heussen,Lothar Rink +10 more
TL;DR: A cytokine profile of pure human neutrophils is established and it is demonstrated that minor contamination of peripheral blood mononuclear cells (PBMCs) in PMN preparations can lead to false‐positive results.
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Metal transporter Slc39a10 regulates susceptibility to inflammatory stimuli by controlling macrophage survival
Hong Gao,Lu Zhao,Hao Wang,Hao Wang,Enjun Xie,Xinhui Wang,Qian Wu,Yingying Yu,Xuyan He,Hongbin Ji,Lothar Rink,Junxia Min,Fudi Wang,Fudi Wang +13 more
TL;DR: It is found that Slc39a10 plays an essential role in macrophage survival by mediating Zn homeostasis in response to LPS stimulation, and a role for SLC39A10 in regulating the survival of macrophages via a Zn/p53-dependent axis during the inflammatory response is identified.
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Chelation of Free Zn2+ Impairs Chemotaxis, Phagocytosis, Oxidative Burst, Degranulation, and Cytokine Production by Neutrophil Granulocytes
TL;DR: Free intracellular Zn2+ plays essential roles in multiple neutrophil functions, affecting extravasation to the site of the infection, uptake and killing of microorganisms, and inflammation.
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