Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
Chat about Author
Papers
Disturbed zinc homeostasis in diabetic patients by in vitro and in vivo analysis of insulinomimetic activity of zinc.
Judith Jansen,Eva Rosenkranz,Silke Overbeck,Sabine Warmuth,Eugenio Mocchegiani,Robertina Giacconi,Ralf Weiskirchen,Wolfram Karges,Lothar Rink +8 more
TL;DR: It is shown that type 1 and type 2 diabetic patients suffer from zinc deficiency, and zinc supplementation may qualify as a potential treatment adjunct in type 2 diabetes by promoting insulin signaling, especially in zinc-deficient subjects.
126
Major depressive disorder is associated with elevated monocyte counts
TL;DR: It is demonstrated that monocytes may play a role in the acute phase of depression and could provide an explanation for immunological dysfunction in depressive states.
124
Zinc supplementation reconstitutes the production of interferon-alpha by leukocytes from elderly persons.
TL;DR: It is reported that peripheral white blood cells from 16 subjects with amean age of 72 years yielded less IFN when stimulated with a virus in vitro than those from 16 young adults with a mean age of 28 years.
123
Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions
Laura Kahmann,Peter Uciechowski,Sabine Warmuth,Birgit Plümäkers,Axel M. Gressner,Marco Malavolta,Eugenio Mocchegiani,Lothar Rink +7 more
TL;DR: The experiments show that adjustment of labile zinc by moderate zinc supplementation reduces spontaneous cytokine release and defects in termination of inflammatory activity, which results in reduced amounts of unspecific preactivated T cells and leads to improved T cell response upon mitogenic stimulation.
122
T-Lymphocytes: A Target for Stimulatory and Inhibitory Effects of Zinc Ions
TL;DR: Taking together, zinc homeostasis influences T-lymphocytes via several molecular targets, leading to a modulation of T-cell-dependent immune responses, which increases the risk for infections and restores normal immune function.