Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Zinc differentially regulates mitogen-activated protein kinases in human T cells
TL;DR: Investigation of the activation of p38 by zinc demonstrated that this MAPK is responsible for the zinc-mediated activation of CREB and mRNA expression of the Th1 cytokines interferon-gamma and interleukin-2, and regulation of MAPK activity contributes to the impact of zinc on T-cell function.
B cell activation and proliferation increase intracellular zinc levels
TL;DR: Free zinc levels in in vitro activated B cells and in freshly isolated B cells expressing the activation marker CD69 were determined, suggesting that activation and proliferation, but not immortalization, act as crucial factors for the elevation of intracellular free zinc.
•Journal Article
Zinc deficiency adversely influences interleukin-4 and interleukin-6 signaling.
TL;DR: Opposition effects of zinc deficiency on IL-4 and IL-6/IL-2 signaling pathways are shown, thus underlying the importance of zinc for proper immune function.
Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration.
Eva Rosenkranz,Martina Maywald,Ralf-Dieter Hilgers,Anne Brieger,Tim Clarner,Markus Kipp,Markus Kipp,Birgit Plümäkers,Sören Meyer,Tanja Schwerdtle,Lothar Rink +10 more
TL;DR: Cumulatively, zinc supplementation seems to be capable to induce tolerance in unwanted immune reactions by increasing iTreg cells, which makes zinc a promising future tool for treating autoimmune diseases without suppressing the immune system.
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9.
TL;DR: In this article, the expression of all characterized human zinc exporters (hZnT-1-9) in different leukocyte subsets in response to zinc supplementation and depletion and analyzed their influence on alterations in the intracellular zinc concentration.