Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Experimental peri-implant mucositis around titanium and zirconia implants in comparison to a natural tooth: part 1-host-derived immunological parameters.
Kim Clever,Karl Andreas Schlegel,Heinz Kniha,Georg Conrads,Lothar Rink,Ali Modabber,Frank Hölzle,Kristian Kniha +7 more
TL;DR: The soft tissue around titanium implants developed a stronger inflammatory response to experimental plaque accumulation in terms of IL-1β values, whereas the teeth presented an increase in IL-6 and TNF-α values.
Zinc chelation decreases IFN-β-induced STAT1 upregulation and iNOS expression in RAW 264.7 macrophages.
Cathleen Reiber,Anne Brieger,Gabriela Engelhardt,Silke Hebel,Lothar Rink,Hajo Haase,Hajo Haase +6 more
TL;DR: Long term Zn2+ chelation does affect STAT1 protein expression, but interferes with NO production by a different, yet unknown pathway not involving STAT1, but there might still be effects on targets other than iNOS.
Zinc in pharmacological doses suppresses allogeneic reaction without affecting the antigenic response.
TL;DR: In in vitro experiments, it is shown that zinc maintains the antigenic potency of the host while blocking the allogeneic response, which is the first step towards a new generation of immunosuppressants.
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases.
TL;DR: This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination.
The influence of naturally occurring heterophilic anti-immunoglobulin antibodies on direct measurement of serum proteins using sandwich ELISAs.
TL;DR: It is demonstrated that two different groups of naturally occurring heterophilic antibodies (IgG-type) are responsible for false-positive IgG rheumatoid factor levels obtained using a commercially available ELISA.