Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Zinc supplementation induces CD4 + CD25 + Foxp3 + antigen-specific regulatory T cells and suppresses IFN-γ production by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1
Martina Maywald,Lothar Rink +1 more
TL;DR: Zinc supplementation on antigen-specific T cells in physiological doses provokes a significant amelioration of cell proliferation and pro-inflammatory cytokine production after reactivation compared to untreated controls, and can be seen as an auspicious tool for inducing tolerance in adverse immune reactions.
Toward Clinical Application of Leukocyte Counts Based on Targeted DNA Methylation Analysis.
Stephanie Sontag,Ledio Bocova,W. H. G. Hubens,Selina Nüchtern,Matthis Schnitker,Thomas Look,Kema M Schröder,Birgit Plümäkers,Vithurithra Tharmapalan,Martina Wessiepe,Thomas Krausz,Jan Kramer,Lothar Rink,Steffen Koschmieder,Wolfgang Wagner +14 more
TL;DR: Targeted DNAm analysis by pyrosequencing or ddPCR is a valid alternative to quantify leukocyte subsets, but some assays require further optimization.
Increase of the Intracellular Zinc Concentration Leads to an Activation and Internalisation of the Epidermal Growth Factor Receptor in A549 Cells.
TL;DR: In this paper, the effect of zinc on the epidermal growth factor receptor (EGFR) activation and its endocytosis was investigated in the alveolar carcinoma cell line A549.
Alterations in membrane fluidity are involved in inhibition of GM-CSF-induced signaling in myeloid cells by zinc.
TL;DR: It is hypothesized that the incubation with zinc causes an alteration of membrane fluidity that hinders efficient receptor assembly as well as phosphorylation of signal molecules and therefore signal transduction.
Recent progress in the tumor necrosis factor-alpha field.
Lothar Rink,Holger Kirchner +1 more
TL;DR: The progress in the field of TNF is focussed on gene organization and transcription, gene polymorphism, biochemistry ofTNF, TNF receptors and the biological role of T NF in autoimmune diseases, infectious diseases, transplantation, cancer and TNF functions on endothelial cells.