Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Leukemia cells accumulate zinc for oncofusion protein stabilization.
Richard Görg,Anna Büttgenbach,Jana Jakobs,Fatıma Hacer Kurtoğlu Babayev,Benjamin Rolles,Lothar Rink,Inga Wessels +6 more
TL;DR: Flow cytometric analyses revealed elevated free intracellular zinc levels in various leukemia cells, which may play a role in stabilizing oncofusion proteins in leukemia and thus support cell proliferation and malignancy, and potential pathways underlying the effects of zinc deficiency in leukemia cells are uncovered.
Zinc Ionophore Pyrithione Mimics CD28 Costimulatory Signal in CD3 Activated T Cells
Jana Jakobs,Lothar Rink +1 more
TL;DR: It is found that zinc signals can function as a costimulatory signal for T helper cell 1 differentiation when T cells are activated only via CD3, which demonstrates the importance of zinc signaling alongside calcium signaling in T cell differentiation.
Zinc deficiency drives Th17 polarization and promotes loss of Treg cell function
TL;DR: An adequate zinc homeostasis is fundamental to slow down or probably stop the progression of autoimmune diseases and infections and supplementing zinc might be a therapeutic approach to dampen autoimmune diseases connected to Th17 cells.
Epigenetic Leukocyte Counts from Dried Blood Spots of Pediatric Patients.
Wouter H G Hubens,Lara Kluge,Alexander Seitz,Eva Verjans,Lothar Rink,Wolfgang Wagner +5 more
TL;DR: Researchers developed a method to quantify epigenetic leukocyte counts from dried blood spots of pediatric patients, enabling non-invasive monitoring of immune cell epigenetics in children, with potential applications in pediatric disease diagnosis and treatment.
The superantigen staphylococcal enterotoxin A (SEA) and monoclonal antibody L243 share a common epitope but differ in their ability to induce apoptosis via MHC-II.
TL;DR: It is concluded that the spatial orientation of dimerized MHC-II and their associated proteins is an important factor for the nature of the transduced signal and consequently the outcome of functional responses.