Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
The biochemical effects of extracellular Zn 2+ and other metal ions are severely affected by their speciation in cell culture media
TL;DR: The role of culture conditions in investigations with zinc ions (Zn(2+)) is explored, which leads to systematic over-estimation of the effects of extracellular metal ions when standard cell culture conditions are used as model systems for assessing potential in vivo effects.
Zinc inhibits the mixed lymphocyte culture.
TL;DR: It is found that slightly elevated zinc concentrations (three to four times the physiological level), which do not decrease T-cell proliferation in vitro nor produce immunosuppressive effects in vivo, suppress alloreactivity in the mixed lymphocyte culture.
Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales
Christina Schier,Martin C.H. Gruhlke,Georg Reucher,Alan J. Slusarenko,Lothar Rink +4 more
TL;DR: The potential of allicin, a sulfur-containing defense compound from garlic, to combat zygomycete fungi is shown and a synergistic interaction between allicin and the non-volatile ampB is revealed.
Metal transporter Slc30a1 controls pharyngeal neural crest differentiation via the zinc-Snai2-Jag1 cascade
Zhidan Xia,Xinying Bi,Xinying Bi,Sisi Yang,Xiu Yang,Zijun Song,Jiayu Wei,Pengfei Xu,Lothar Rink,Junxia Min,Fudi Wang,Fudi Wang +11 more
TL;DR: Findings indicate that the Slc30a1/zinc‐snai2‐jag1b axis is an essential regulatory network controlling PA differentiation, shedding new light on the function of zinc homeostasis in maintaining NC cell stemness and multipotency in vertebrates.
Stimulation of Human Peripheral Blood Mononuclear Cells by Zinc and Related Cations
TL;DR: It is shown that zinc addition in a serum- and lipopolysaccharide-free cell culture system leads to significantly enhanced levels of interleukin 1 beta and tumour necrosis factor alpha and to expression of the corresponding mRNA in human peripheral blood mononuclear cells (PBMC).