Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Signal transduction in monocytes: the role of zinc ions.
Hajo Haase,Lothar Rink +1 more
TL;DR: The availability of zinc has a regulatory role in the immune system and can have either pro- or anti-inflammatory effects, which both seem to be a consequence of a direct interaction of zinc with the cytokine secretion by monocytes.
Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects.
Eva Rosenkranz,Ralf-Dieter Hilgers,Peter Uciechowski,Arnd Petersen,Birgit Plümäkers,Lothar Rink +5 more
TL;DR: Zinc may regulate unwanted hyperresponsive immune reactions by suppressing proliferation through a significant shift from IL-10 to the Th1 cytokine IFN-γ, and enhanced regulatory T cell numbers, without negatively affecting the immune system.
Regulation of the Interleukin-6 gene expression during monocytic differentiation of HL-60 cells by chromatin remodeling and methylation
TL;DR: DNA methylation appears to be the essential epigenetic mechanism in IL-6 gene expression of mature monocytes and their progenitors by controlling the chromatin structure during monopoiesis.
Zinc deficiency and IL-6 −174G/C polymorphism in old people from different European countries: Effect of zinc supplementation. ZINCAGE study
Eugenio Mocchegiani,Robertina Giacconi,Laura Costarelli,Elisa Muti,Catia Cipriano,Silvia Tesei,Sara Pierpaoli,Cinzia Giuli,Roberta Papa,Fiorella Marcellini,Nazzarena Gasparini,Romeo Pierandrei,Francesco Piacenza,Ermina Mariani,Daniela Monti,George Dedoussis,Stavroula Kanoni,Georges Herbein,Tamas Fulop,Lothar Rink,Jolanta Jajte,Marco Malavolta +21 more
TL;DR: The sole assessment of plasma Zn level is not reliable to exclude C- carriers from Zn supplementation, and a possible explanation for the conflicting data on the identification of IL-6-174G as a "risk allele" based on different dietary intake in the studied population is suggested.
Zinc signals in neutrophil granulocytes are required for the formation of neutrophil extracellular traps
TL;DR: Zinc signals are an essential component of the ROS-dependent signal transduction leading to NETosis, and TPEN had no effect on PKC activity and ROS production, indicating that Zn2+ is not required for activation of PKC, but for signals downstream of ROS production.