Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Zinc and the Altered Immune System in the Elderly
Hajo Haase,Lothar Rink +1 more
- 01 Jan 2007
TL;DR: It is argued that zinc deficiency contributes to immunosenescence, supported by several studies showing that zinc supplementation has a beneficial effect on immune function of elderly people and reverses several changes associated with immunosenscence.
Impaired serum cortisol stress response is a predictor of early relapse.
Klaus Junghanns,Jutta Backhaus,U. Tietz,Wolfgang Lange,J. Bernzen,T. Wetterling,Lothar Rink,Martin Driessen +7 more
TL;DR: During early abstention from alcohol, reduced stress-responsivity of the hypothalamo-pituitary-adrenocortical axis seems to be connected to early relapse.
Increase of Intracellular Zinc Levels Rather Than Zinc Influx Inhibits Interleukin‐2 Production in Zinc Supplemented Jurkat Cells
Christian M Sobernig,Henrike J Fischer,Lothar Rink,Jana Jakobs +3 more
TL;DR: Zinc supplementation suppresses IL-2 production in Jurkat T cells, particularly when intracellular zinc levels are elevated, rather than zinc influx inhibition, suggesting a role for zinc in stabilizing phosphorylated NFAT and blocking IL-2 expression.
The human allicin-proteome : S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
Martin C.H. Gruhlke,Haike Antelmann,Jörg Bernhardt,Veronika Kloubert,Lothar Rink,Alan J. Slusarenko +5 more
TL;DR: This study revealed the widespread extent of S‐thioallylation in the human Jurkat cell proteome and showed effects of allicin exposure on essential cellular functions of selected targets, many of which are targets for cancer therapy.
Leukocyte Counts Based on DNA Methylation at Individual Cytosines.
Joana Frobel,Tanja Božić,Michael Lenz,Michael Lenz,Peter Uciechowski,Yang Han,Reinhild Herwartz,Klaus Strathmann,Susanne Isfort,Jens Panse,André Esser,Carina Birkhofer,Uwe Gerstenmaier,Thomas Kraus,Lothar Rink,Steffen Koschmieder,Wolfgang Wagner +16 more
TL;DR: White blood cell counts can be reliably determined by site-specific DNAm analysis and is applicable to very small blood volumes and frozen samples, and it allows for more standardized and cost-effective analysis in clinical application.