Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
Chat about Author
Papers
Mycoplasma arthritidis-derived superantigen (MAM) displays DNase activity.
TL;DR: Overexpression of Mycoplasma arthritidis-derived superantigen in Escherichia coli reduced bacterial growth, which is unique, as staphylococcal enterotoxin A and toxic shock syndrome toxin-1, expressed in the same vector system, showed no growth impairment.
13
Effects of human Toll-like receptor 1 polymorphisms on ageing
Peter Uciechowski,Eva Maria Oellig,Erminia Mariani,Marco Malavolta,Eugenio Mocchegiani,Lothar Rink +5 more
TL;DR: The higher frequency of the TLR1pos genotypes in elderly Italian subjects may result from different ethnic populations, and future studies are needed to elucidate the association of a TLRpos genotype with decreased susceptibility to infections and reduced risk to develop artherosclerosis.
•Journal Article
Identification of HLA-DRB1 and HLA-DQB1 identical individuals by a cytokine-based mixed lymphocyte culture.
TL;DR: In conclusion, cytokine determination in MLC is a new method of evaluating the biological relevance of stimulatory antigens after allogeneic stimulation detecting all individual diversities in one experiment.
12
Short-term zinc supplementation of zinc-deficient seniors counteracts CREMα - mediated IL-2 suppression
Bastian Robinson Baarz,Thea Laurentius,Jana Wolf,Inga Wessels,L. Cornelius Bollheimer,Lothar Rink +5 more
TL;DR: For example, this article showed that zinc deficiency-induced decrease in IL-2 production in the elderly can be alleviated by short-term zinc supplementation and showed that an average of only 6 days of in vivo zinc supplementation to zinc-deficient seniors was sufficient to rapidly improve zinc status, reverse CREM overexpression, and counteract subsequent impaired IL2 production, and vice versa.
Microbial superantigens stimulate T cells by the superantigen bridge and independently by a cytokine pathway.
TL;DR: It is found that TSST-1, ExFTA, and SEC3 differed from all other superantigens tested because they stimulated a stronger monokine release and showed indirect (mitogenic) side effects.
12