Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Lead ions abrogate lipopolysaccharide-induced nitric monoxide toxicity by reducing the expression of STAT1 and iNOS
TL;DR: A concentration-dependent protection of BV-2 microglia and RAW 264.7 macrophages by Pb(2+) against lipopolysaccharide (LPS)-induced toxicity is observed, explaining the reduced formation of NO and a subsequent increase of cellular viability in vitro.
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Update on the multi-layered levels of zinc-mediated immune regulation.
TL;DR: The current understanding of the role of zinc during the immune response focusing on the most recent findings and underlying mechanisms is described.
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Effects of long-term zinc supplementation and deprivation on gene expression in human THP-1 mononuclear cells.
Dawn J. Mazzatti,Peter Uciechowski,Silke Hebel,Gabriela Engelhardt,Andrew White,Jonathan Richard Powell,Lothar Rink,Hajo Haase +7 more
TL;DR: Microarray technology was used to assess the effects of zinc supplementation and depletion on global gene expression, and functional networks were analyzed, showing that the well known effect of zinc on pro-inflammatory cytokines is not limited to these genes; it acts on a number of functionally connected genes, as well.
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Exclusion of bioactive contaminations in Streptococcus pyogenes erythrogenic toxin A preparations by recombinant expression in Escherichia coli.
Ursula Fagin,Ulrich Hahn,Joachim Grötzinger,B Fleischer,D Gerlach,F Buck,A Wollmer,Holger Kirchner,Lothar Rink +8 more
TL;DR: The results represent for the first time the production in E. coli of recombinant SPEA with the authentic N-terminal sequence and a proven superantigenic activity and indicate that immunological studies of superantigens require highly purified substances free of biologically active contaminations.
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Vitamin D3 and zinc synergistically induce regulatory T cells and suppress interferon-γ production in mixed lymphocyte culture.
TL;DR: In this article , the combined action of zinc and vitamin D3 in different in vitro models for immune reactions was investigated, and it was shown that zinc augments the effect of vitamin D-3 in certain therapeutic and sub-therapeutic concentrations.
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