Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Mercuric ions inhibit mitogen-activated protein kinase dephosphorylation by inducing reactive oxygen species.
TL;DR: Three potential ways in which Hg(2+) ions could inhibit MAPK dephosphorylation in the human T-cell line Jurkat are investigated: by direct binding to phosphatases; by releasing cellular zinc (Zn(2+); and by inducing reactive oxygen species (ROS).
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Influence of +1245 A/G MT1A polymorphism on advanced glycation end-products (AGEs) in elderly: effect of zinc supplementation.
Robertina Giacconi,Andreas Simm,Alexander Navarrete Santos,Laura Costarelli,Marco Malavolta,Patrizia Mecocci,Francesco Piacenza,Andrea Basso,Tamas Fulop,Lothar Rink,George Dedoussis,Stavroula Kanoni,Georges Herbein,Jolanta Jajte,Eugenio Mocchegiani +14 more
TL;DR: Investigation of +1245 A/G MT1A polymorphism found increased plasma AGEs and ROS production in PBMCs at baseline and a higher improvement in iZnL after zinc intervention with respect to G− individuals and no significant changes after zinc supplementation were observed for A GEs, ROS and MT levels as well as for enzyme antioxidant activity in relation to the genotype.
Dendritic cell subsets in lymph nodes are characterized by the specific draining area and influence the phenotype and fate of primed T cells
Ulrike Bode,Marc Lörchner,Manuela Ahrendt,Maike Blessenohl,Kathrin Kalies,Anja Claus,Silke Overbeck,Lothar Rink,Reinhard Pabst +8 more
TL;DR: The results show that the region‐specific DC have a unique phenotype and an impact on the ratio of CD4 : CD8 T cells during an immune response in vivo.
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Application of Zinpyr-1 for the investigation of zinc signals in Escherichia coli
TL;DR: This manuscript explores the use of the low molecular weight fluorescent probe Zinpyr-1 in E. coli and finds that the probe detects free Zn2+ in these bacteria, suggesting that other processes could be controlled by the free intracellular Zn 2+ concentration.
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