Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Metallothionein downregulation in very old age: a phenomenon associated with cellular senescence?
Marco Malavolta,Catia Cipriano,Laura Costarelli,Robertina Giacconi,Silvia Tesei,Elisa Muti,Francesco Piacenza,Sara Pierpaoli,Annis Larbi,Graham Pawelec,George Dedoussis,George Herbein,Daniela Monti,Jolanta Jajte,Lothar Rink,Eugenio Mocchegiani +15 more
TL;DR: It is reported that metallothionein protein levels also decrease in very old age, and that this is independent of dietary zinc intake, suggesting that phenomena observed invery old people can be at least partially attributed to diminished cell proliferation.
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Zinc homeostasis in aging: two elusive faces of the same "metal".
Eugenio Mocchegiani,Laura Costarelli,Robertina Giacconi,Catia Cipriano,Elisa Muti,Lothar Rink,Marco Malavolta +6 more
TL;DR: It should be more correct to talk about aging as a condition associated with zinc dyshomeostasis rather than deficiency, because restoring functional zinc homeostasis in aging people is an attractive field for antiaging research, but requires further knowledge than the current state of the art.
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Induction of a Proinflammatory Cytokine Network by Mycoplasma arthritidis-Derived Superantigen (MAS)
TL;DR: Investigation of MAS-specific cytokine induction in humans and mice found an overproduction of proinflammatory cytokines and a significantly decreased capacity to induce the anti-inflammatory cytokine IL-10 and IL-1RA, which may explain an MHC linkage.
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Evidence for presence of lgG4 anti-immunoglobulin autoantibodies in all human beings
TL;DR: It is suggested that IgG4 anti-IgA antibodies (the strongest found heterophilic Immunoglobulins) are responsible for most artifacts obtained with commercial EUSA systems.
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One-way synergistic effect of low superantigen concentrations on lipopolysaccharide-induced cytokine production.
TL;DR: An in vitro mixed sepsis model is developed investigating the effect of different superantigen doses, in combination with different LPS concentrations, on cytokine production in human PBMCs using ELISA and RT-PCR and supports the idea that this interaction is one important crossover point of signal transduction pathways by LPS and superantigens, which seems to be predominantly regulated by IFN-gamma and PGE-2.
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