Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Polymorphisms in tumour necrosis factor and adhesion molecule genes in patients with inflammatory bowel disease: associations with HLA-DR and -DQ alleles and subclinical markers.
TL;DR: TNF2 and HLA-DRB1*15 alleles were associated with ANCA-positive UC in the investigated population, suggesting that ANCA might be a useful marker, at least in some ethnic groups, for dividing IBD patients into genetically more homogeneous subgroups.
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Functional Analysis of Mycoplasma arthritidis-Derived Mitogen Interactions with Class II Molecules
Chantale Bernatchez,Reem Al-Daccak,Pierre Etongué Mayer,Khalil Mehindate,Lothar Rink,Salah Mecheri,Walid Mourad +6 more
TL;DR: The data presented indicate that MAM-induced cytokine gene expression in human monocytes is Zn2+ dependent, and it seems that SEA and MAM interact with the same or overlapping binding sites on the MHC class II beta chain and, on the other hand, that they bind to the alpha chain most probably through the regions that are involved in SEB and TSST-1 binding.
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Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes.
TL;DR: Experiments in the T lymphocyte cell line Jurkat and primary human lymphocytes show that TMS and its active metabolite, ethyl mercury, cause an increase in signal intensity with probes designed for the detection of either calcium or zinc ions.
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Zinc deficiency as a possible risk factor for increased susceptibility and severe progression of Corona Virus Disease 19.
TL;DR: In this paper, a review of known Zn deficiency effects in the context of an infection with Severe Acute Respiratory Syndrome-Coronavirus-2 and its currently known pathogenic mechanisms was presented.
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Differential induction of tumor necrosis factor alpha in murine and human leukocytes by Mycoplasma arthritidis-derived superantigen.
TL;DR: The failure of MAS to induce TNF-alpha in human peripheral blood mononuclear cells is specific forMAS and not common to all superantigens, and the direct activation of bone marrow-derived macrophages also seems to be specific for MAS.
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