Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Parameters Influencing Zinc in Experimental Systems in Vivo and in Vitro
Johanna Ollig,Veronika Kloubert,Inga Weßels,Hajo Haase,Lothar Rink +4 more
- 21 Mar 2016
TL;DR: In this article, a review summarizes the difficulties and major pitfalls when working with zinc in in vitro and in vivo research and specifies important aspects for zinc substitution and supplementation, including the bioavailability of zinc and its intestinal absorption.
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Differential Gene Expression after Zinc Supplementation and Deprivation in Human Leukocyte Subsets
Hajo Haase,Dawn J. Mazzatti,Andrew White,Klaus H. Ibs,Gabriela Engelhardt,Silke Hebel,Jonathan Richard Powell,Lothar Rink +7 more
TL;DR: Microarray technology used to analyze and compare the changes in mRNA expression in cell culture models of monocytes, T cells, and B cells in response to supplementation with zinc revealed that zinc affects entire functional networks of genes that are related to proinflammatory cytokines and cellular survival.
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Zinc supplementation augments TGF-β1-dependent regulatory T cell induction.
TL;DR: Combined zinc and TGF‐β1 treatment provoked an increased Treg cell induction due to a triggered intracellular zinc signal, which in association with an increased Smad 2/3 activation leads to a boosted Foxp3 expression and resulting in an ameliorated allogeneic reaction in MLC.
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A short 18 items food frequency questionnaire biochemically validated to estimate zinc status in humans.
TL;DR: The 18 items FFQ seems to be a sufficient tool to provide a good estimation of the zinc status and shortening of the questionnaire to 18 items without a loss of predictive efficiency enables a facilitated and resource-saving routine use.
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T-helper type 1 cytokine release is enhanced by in vitro zinc supplementation due to increased natural killer cells
Claudia H.D. Metz,Anja K. Schröder,Silke Overbeck,Laura Kahmann,Birgit Plümäkers,Lothar Rink +5 more
TL;DR: A nutritional intake of 10 mg of zinc increases the quantity of interferon-gamma-producing natural killer cells and strengthens the immune system against neoplasms and viral infections.
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