Lothar Rink
RWTH Aachen University
262 Papers
1.1K Citations
Lothar Rink is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Zinc & Immune system. The author has an hindex of 63, co-authored 235 publications. Previous affiliations of Lothar Rink include University of Lübeck & Laval University.
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Papers
Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study.
Eugenio Mocchegiani,Robertina Giacconi,Catia Cipriano,Laura Costarelli,Elisa Muti,Silvia Tesei,Cinzia Giuli,Roberta Papa,Fiorella Marcellini,Erminia Mariani,Lothar Rink,George Herbein,Audrey Varin,Tamas Fulop,Daniela Monti,Jolanta Jajte,George Dedoussis,Efstathios S. Gonos,Ioannis P. Trougakos,Marco Malavolta +19 more
TL;DR: In this study, the selection of elderly subjects for zinc supplementation is discussed in relation to the genetic background of MT and pro‐inflammatory cytokines, such as interleukin‐6, because the latter is involved both in MT‐gene expression and in intracellular zinc homeostasis.
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•Journal Article
Zinc enhances lipopolysaccharide-induced monokine secretion by alteration of fluidity state of lipopolysaccharide.
Nele Wellinghausen,Andra B. Schromm,Ulrich Seydel,Klaus Brandenburg,Jürgen Luhm,Holger Kirchner,Lothar Rink +6 more
TL;DR: The data indicate that the zinc level represents a relevant clinical parameter in the treatment of Gram-negative infection, and reveals potential risks in the therapeutic application of zinc.
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PTEN-inhibition by zinc ions augments interleukin-2-mediated Akt phosphorylation
Laura Marie Plum,Anne Brieger,Gabriela Engelhardt,Silke Hebel,Andreas Nessel,Marcus Arlt,Jennifer Kaltenberg,Ulrich Schwaneberg,Michael Huber,Lothar Rink,Hajo Haase +10 more
TL;DR: It is hypothesized that zinc signals affect the IL-2-dependent PI3K/Akt pathway by inhibiting the negative regulator PTEN through binding with a sub-nanomolar affinity to cysteine residues that are essential for its catalytic activity.
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Superantigen Genes Are More Important than the emm Type for the Invasiveness of Group A Streptococcus Infection
Maria Lintges,Mark van der Linden,Ralf-Dieter Hilgers,Sabine Arlt,Adnan Al-Lahham,Ralf René Reinert,Stefan Plücken,Lothar Rink +7 more
TL;DR: The results indicate that the presence of superantigen genes is more important for the invasiveness of group A Streptococcus infection than emm type and may be the connection between the high-risk HLA type of the host and the pathogen.
Influence of zinc supplementation on immune parameters in weaned pigs.
TL;DR: The immune status of weaned pigs was analyzed under different conditions of zinc supplementation and genome comparisons indicate that the porcine genome is more closely related to the human genome than the murine genome, which might make the pig a suitable organism to study human immunity and diseases.
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