Lorena Barclay
BC Cancer Agency
6 Papers
44 Citations
Lorena Barclay is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Reed–Sternberg cell & Gene. The author has an hindex of 4, co-authored 6 publications.
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Papers
Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome.
Christian Steidl,Adele Telenius,Sohrab P. Shah,Pedro Farinha,Lorena Barclay,Merrill Boyle,Joseph M. Connors,Douglas E. Horsman,Randy D. Gascoyne +8 more
TL;DR: It is shown that doxorubicin exposure to KMH2 inducesABCC1 expression and that siRNA silencing of ABCC1 sensitizes K MH2 cells to doxorbicin toxicity in vitro, suggesting that overexpression of ABC C1 contributes to the drug resistance phenotype found in KMH 2.
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Correlations of EGFR mutations and increases in EGFR and HER2 copy number to gefitinib response in a retrospective analysis of lung cancer patients
Trevor J. Pugh,Gwyn Bebb,Lorena Barclay,Margaret Sutcliffe,John Fee,Chris Salski,Robert O'Connor,Cheryl Ho,Nevin Murray,Barbara Melosky,John C. English,Jeurgen Vielkind,Doug Horsman,Janessa Laskin,Marco A. Marra +14 more
TL;DR: In this paper, the authors examined the relationship between response and the molecular status of two tyrosine kinases, EGFR and HER2, in 39 patients treated with gefitinib at the BC Cancer Agency.
Genetic Alterations Detected by High-Resolution Array Comparative Genomic Hybridization in Microdissected HRS Cells Correlate with Treatment Outcome in Classical Hodgkin Lymphoma
Christian Steidl,Adele Telenius,Sohrab P. Shah,K-John Cheung,Lorena Barclay,Joseph M. Connors,Douglas E. Horsman,Randy D. Gascoyne +7 more
TL;DR: The combination of laser microdissection with subsequent WGA and high resolution array CGH provides a robust and sensitive platform for detecting chromosomal imbalances in microdissected HRS cells and found copy number alterations that are significantly associated with disease progression which, therefore, could serve as predictive factors for treatment outcome.
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CSF1R Expression of Hodgkin Reed Sternberg Cells Is Associated with the Number of Macrophages in the Tumor Microenvironment and Is Correlated with Treatment Outcome
Christian Steidl,Arjan Diepstra,Tang Lee,Pedro Farinha,Adele Telenius,Merrill Boyle,Sohrab P. Shah,Lorena Barclay,Anke van den Berg,Kerry J. Savage,Joseph M. Connors,Randy D. Gascoyne +11 more
TL;DR: The correlation of CSF1R expression in HRS cells with numbers of tumor-associated macrophages in the microenvironment suggests a functionally important interaction of H RS cells withmacrophages via CSF-1 receptor signaling, which might be useful for risk stratification in future clinical trials.
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Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients.
Trevor J. Pugh,Mira Keyes,Lorena Barclay,Allen Delaney,Martin Krzywinski,Dallas Thomas,Karen Novik,Cindy Yang,Alexander Agranovich,Michael McKenzie,W. Jim Morris,Peggy L. Olive,Marco A. Marra,Richard A. Moore +13 more
TL;DR: Variants in three DNA repair genes were linked to increased radiosensitivity but require validation in larger populations, indicating that existing sequence databases do not fully represent the full extent of sequence variation.