Loren Laine
Yale University
382 Papers
3.2K Citations
Loren Laine is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Upper gastrointestinal bleeding. The author has an hindex of 82, co-authored 348 publications. Previous affiliations of Loren Laine include Oregon Health & Science University & McMaster University.
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Papers
Evaluation of proton pump inhibitor use in patients with acute coronary syndromes based on risk factors for gastrointestinal bleed.
TL;DR: Use of PPI following ACS is modest, although it did increase with an increasing number of previously identified GI risk factors, and larger studies are warranted to validate prior, or identify new, risk factors as predictors of long-term bleeding, and improve awareness of GI bleeding risk such that use of P PI could be optimized.
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Is an evidence-based approach to creating guidelines always the right one?
Michael Fried,Eamonn Martin Quigley,Richard H. Hunt,Gordon H. Guyatt,Benjamin O. Anderson,David J. Bjorkman,Michael J.G. Farthing,Suleiman S. Fedail,Ronald Green-Thompson,John G. Hampton,Justus Krabshuis,Loren Laine,Richard Horton +12 more
TL;DR: This Viewpoint article discusses the development of guidelines using an evidence-based approach and whether this approach is applicable worldwide.
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Factors impacting physicians’ decisions to prevent variceal hemorrhage
Kathleen Yan,John F.P. Bridges,Salvador Augustin,Loren Laine,Guadalupe Garcia-Tsao,Liana Fraenkel +5 more
TL;DR: Among physicians, where the majority performs endoscopy on two or more days per week, most prefer prevention strategies which include EVL, due to the strong appeal of being able to visualize eradication of varices.
Is it time for quadruple therapy to be first line
TL;DR: The most commonly used regimen for Helicobacter pylori therapy at present is twice-daily proton pump inhibitor (PPI)-based triple therapy, which has similar rates of compliance and adverse events.