Loralyn A. Benoit
Washington University in St. Louis
5 Papers
Loralyn A. Benoit is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Innate immune system & Natural killer T cell. The author has an hindex of 5, co-authored 5 publications.
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Papers
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8α+ conventional dendritic cells
Brian T. Edelson,Wumesh Kc,Richard Juang,Masako Kohyama,Loralyn A. Benoit,Paul A. Klekotka,Clara Moon,Jörn C. Albring,Wataru Ise,Drew G. Michael,Deepta Bhattacharya,Thaddeus S. Stappenbeck,Michael J. Holtzman,Sun-Sang J. Sung,Theresa L. Murphy,Kai Hildner,Kenneth M. Murphy +16 more
TL;DR: Evidence is provided for a developmental relationship between lymphoid organ–resident CD8α+ cDCs and nonlymphoid CD103+ DCs and their shared developmental dependence on the transcription factor Irf8.
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Melanoma differentiation-associated gene 5 (MDA5) is involved in the innate immune response to Paramyxoviridae infection in vivo.
Leonid Gitlin,Loralyn A. Benoit,Christina Song,Marina Cella,Susan Gilfillan,Michael J. Holtzman,Marco Colonna +6 more
TL;DR: It is demonstrated that MDA5 is indispensable for sustained expression of IFN in response to paramyxovirus infection and the first evidence of Mda5-dependent containment of in vivo infections caused by (−) sense RNA viruses is provided.
New immune pathways from chronic post-viral lung disease
TL;DR: Two new immune pathways responsible for early and late phases of chronic inflammatory lung disease are identified in experimental and clinical settings and provide useful targets for diagnosis and therapy of this common disorder.
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Immune Pathways for Translating Viral Infection into Chronic Airway Disease
Michael J. Holtzman,Derek E. Byers,Loralyn A. Benoit,John T. Battaile,John T. Battaile,Yingjian You,Eugene Agapov,Chaeho Park,Mitchell H. Grayson,Edy Y. Kim,Anand C. Patel +10 more
TL;DR: An adaptiveimmune response that mediates acute disease and an innate immune response that drives chronic inflammatory lung disease are identified in experimental and clinical settings.
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease.
Edy Y. Kim,John T. Battaile,Anand C. Patel,Yingjian You,Eugene Agapov,Mitchell H. Grayson,Loralyn A. Benoit,Derek E. Byers,Yael G. Alevy,Jennifer Tucker,Suzanne Swanson,Rose M. Tidwell,Jeffrey W. Tyner,Jeffrey D. Morton,Mario Castro,Deepika Polineni,G. Alexander Patterson,Reto A. Schwendener,John Allard,Gary Peltz,Michael J. Holtzman +20 more
TL;DR: It is found that this type of disease arises independently of an adaptive immune response and is driven instead by interleukin-13 produced by macrophages that have been stimulated by CD1d-dependent T cell receptor–invariant natural killer T (NKT) cells.