Lora Boteva
University of Edinburgh
9 Papers
7 Citations
Lora Boteva is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Chromatin & Condensin. The author has an hindex of 4, co-authored 9 publications.
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Papers
SAF-A Regulates Interphase Chromosome Structure through Oligomerization with Chromatin-Associated RNAs
Ryu Suke Nozawa,Lora Boteva,Dinesh C. Soares,Catherine Naughton,Alison R. Dun,Adam Buckle,Bernard Ramsahoye,Peter C. Bruton,Rebecca Sonia Saleeb,Maria Arnedo,Bill Hill,Rory R. Duncan,Sutherland K. Maciver,Nick Gilbert +13 more
TL;DR: In this article, the authors show that SAF-A and caRNAs form a dynamic, transcriptionally responsive chromatin mesh that organizes large-scale chromosome structures and protects the genome from instability.
210
Common Fragile Sites Are Characterized by Faulty Condensin Loading after Replication Stress.
Lora Boteva,Ryu-Suke Nozawa,Catherine Naughton,Kumiko Samejima,William C. Earnshaw,Nick Gilbert +5 more
TL;DR: This model suggests that, in conditions of exogenous replication stress, aberrant condensin loading leads to molecular defects and CFS expression, concomitantly providing an environment for MIDAS, which, if not resolved, results in chromosome instability.
43
The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress.
Lotte P. Watts,Toyoaki Natsume,Toyoaki Natsume,Yuichiro Saito,Javier Garzón,Qianqian Dong,Lora Boteva,Nick Gilbert,Masato T. Kanemaki,Masato T. Kanemaki,Shin-ichiro Hiraga,Anne D. Donaldson +11 more
TL;DR: It is shown that RIF1 must be present both during replication stress and in the ensuing recovery period to promote cell survival, with the Rif1-Long isoform playing a specific role during the ensuing G1 phase in damage site protection.
18
RIF1 and KAP1 differentially regulate the choice of inactive versus active X chromosomes.
Elin Enervald,Elin Enervald,Lynn M. Powell,Lora Boteva,Rossana Foti,Nerea Blanes Ruiz,Gözde Kibar,Agnieszka Piszczek,Fatima Cavaleri,Martin Vingron,Andrea Cerase,Sara B.C. Buonomo,Sara B.C. Buonomo +12 more
TL;DR: This article showed that the mutual exclusion of Tsix and RIF1 at the Xist promoters established a self-sustaining loop that transforms an initially stochastic event into a stably inherited asymmetric X-chromosome state.
12
Common fragile sites are characterised by faulty condensin loading after replication stress
Lora Boteva,Ryu-Suke Nozawa,Catherine Naughton,Kumiko Samejima,William C. Earnshaw,Nick Gilbert +5 more
TL;DR: In this paper, the authors show that cytogenetic and molecular lesions arise due to faulty condensin loading at common fragile sites (CFSs) through a defect in condensins mediated compaction and are coincident with mitotic DNA synthesis (MIDAS).