Lonnie D. Shea
University of Michigan
346 Papers
2.3K Citations
Lonnie D. Shea is an academic researcher from University of Michigan. The author has contributed to research in topics: Gene delivery & Ovarian follicle. The author has an hindex of 75, co-authored 320 publications. Previous affiliations of Lonnie D. Shea include Northwestern University & Georgia Institute of Technology.
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Papers
Intravascular innate immune cells reprogrammed via intravenous nanoparticles to promote functional recovery after spinal cord injury.
Jonghyuck Park,Yining Zhang,Eiji Saito,Steve J. Gurczynski,Bethany B. Moore,Brian J. Cummings,Aileen J. Anderson,Lonnie D. Shea +7 more
TL;DR: It is demonstrated that nanoparticles provide a platform that limits acute inflammation and tissue destruction, at a favorable risk-benefit ratio, leading to a proregenerative microenvironment that supports regeneration and functional recovery.
Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo
Shreyas S. Rao,Grace G. Bushnell,Samira M. Azarin,Graham Spicer,Brian A. Aguado,Jenna R. Stoehr,Eric J. Jiang,Vadim Backman,Lonnie D. Shea,Jacqueline S. Jeruss +9 more
TL;DR: Microporous poly(ε-caprolactone) scaffolds were developed that capture early metastatic cells and thus serve as a sentinel for early detection and may provide diagnostic and therapeutic options for cancer patients in both the high-risk and adjuvant treatment settings.
Tolerogenic Ag-PLG Nanoparticles Induce Tregs to Suppress Activated Diabetogenic CD4 and CD8 T Cells
Suchitra Prasad,Tobias Neef,Dan Xu,Joseph R. Podojil,Daniel R. Getts,Lonnie D. Shea,Stephen D. Miller +6 more
TL;DR: The ability of carboxylated 500 nm biodegradable poly(lactide-co-glycolide) nanoparticles PLG nanoparticles (either surface coupled with or encapsulating the cognate diabetogenic peptides) to rapidly and efficiently restore tolerance in NOD is demonstrated.
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Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury.
TL;DR: In this paper, surface-mediated DNA delivery from multiple channel bridges was applied to deliver lipoplexes in vivo to the injured spinal cord to promote transgene expression in vivo.
94
Inductive tissue engineering with protein and DNA-releasing scaffolds
David M. Salvay,Lonnie D. Shea +1 more
TL;DR: This review summarizes the use of scaffolds in the dual role of structural support for cell growth and vehicle for controlled release of tissue inductive factors, or DNA encoding for these factors.
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