Loic Belloy
Pasteur Institute
8 Papers
8 Citations
Loic Belloy is an academic researcher from Pasteur Institute. The author has contributed to research in topics: Liver X receptor & Mannose receptor. The author has an hindex of 5, co-authored 8 publications. Previous affiliations of Loic Belloy include French Institute of Health and Medical Research.
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Papers
Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
Manuel Lasalle,Vanessa Hoguet,Nathalie Hennuyer,Florence Leroux,Catherine Piveteau,Loic Belloy,Sophie Lestavel,Emmanuelle Vallez,Emilie Dorchies,Isabelle Duplan,Emmanuel Sevin,Maxime Culot,Fabien Gosselet,Rajaa Boulahjar,Adrien Herledan,Bart Staels,Benoit Deprez,Anne Tailleux,Julie Charton +18 more
TL;DR: Among them, compound 24 is a potent GLP-1 secretagogue, has low effect on gallbladder volume, and improves glucose homeostasis in a preclinical murine model of diet-induced obesity and insulin resistance, making the proof of concept of the potential of topical intestinal TGR5 agonists as therapeutic agents in type-2 diabetes.
Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure-Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor.
Vanessa Hoguet,Manuel Lasalle,Mathieu Maingot,Geoffroy Dequirez,Rajaa Boulahjar,Florence Leroux,Catherine Piveteau,Adrien Herledan,Alexandre Biela,Julie Dumont,Oscar Chávez-Talavera,Loic Belloy,Isabelle Duplan,Nathalie Hennuyer,Laura Butruille,Sophie Lestavel,Emmanuel Sevin,Maxime Culot,Fabien Gosselet,Bart Staels,Benoit Deprez,Anne Tailleux,Julie Charton +22 more
TL;DR: In this article, the authors performed the conjugation of polyethylene glycols (220-5000 Da) to a series of non-steroidal small agonists of the bile acids receptor TGR5.
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Clofoctol inhibits SARS-CoV-2 replication and reduces lung pathology in mice
Sandrine Belouzard,Arnaud Machelart,Valentin Sencio,Thibaut Vausselin,Eik Hoffmann,Nathalie Deboosere,Yves Rouillé,Lowiese Desmarets,Karin Séron,Adeline Danneels,Cyril Robil,Loic Belloy,Camille Moreau,Catherine Piveteau,Alexandre Biela,Alexandre Vandeputte,Severine Heumel,Lucie Deruyter,Julie Dumont,Florence Leroux,Ilka Engelmann,Enagnon Kazali Alidjinou,Didier Hober,Priscille Brodin,Terence Beghyn,François Trottein,Benoit Deprez,Jean Dubuisson +27 more
TL;DR: In this article, a library of drug compounds, already registered in one or several geographical areas, was screened to identify those exhibiting antiviral activity against SARS-CoV-2 with relevant potency.
miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
Manjula Vinod,Indumathi Chennamsetty,Sophie Colin,Loic Belloy,Federica De Paoli,Helmut Schaider,Wolfgang F. Graier,Saša Frank,Dagmar Kratky,Bart Staels,Giulia Chinetti-Gbaguidi,Gerhard M. Kostner +11 more
TL;DR: It is shown that miR-206 expression in macrophages is repressed by LXRα activation, while oxidized LDL and inflammatory stimuli profoundly induced miR -206 expression, and proposed a feed-back loop between mi R-206 and LXR α that might be part of an LXR auto-regulatory mechanism to fine tune LXR activity.
Large scale screening discovers clofoctol as an inhibitor of SARS-CoV-2 replication that reduces COVID-19-like pathology
Sandrine Belouzard,Arnaud Machelart,Valentin Sencio,Thibaut Vausselin,Eik Hoffmann,Nathalie Deboosere,Yves Rouillé,Lowiese Desmarets,Karin Séron,Adeline Danneels,Cyril Robil,Loic Belloy,Camille Moreau,Catherine Piveteau,Alexandre Biela,Alexandre Vandeputte,Séverine Heumel,Lucie Deruyter,Julie Dumont,Florence Leroux,Ilka Engelmann,Enagnon Kazali Alidjinou,Didier Hober,Priscille Brodin,Terence Beghyn,François Trottein,Benoit Deprez,Jean Dubuisson +27 more
TL;DR: In this paper, a library of drug compounds, already registered in one or several geographical areas, was used to identify those exhibiting antiviral activity against SARS-CoV-2 with relevant potency.