Liyuan Hu
Jilin University
6 Papers
Liyuan Hu is an academic researcher from Jilin University. The author has contributed to research in topics: Bacteriophage & Staphylococcus aureus. The author has an hindex of 6, co-authored 6 publications.
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Papers
The Bacteriophage EF-P29 Efficiently Protects against Lethal Vancomycin-Resistant Enterococcus faecalis and Alleviates Gut Microbiota Imbalance in a Murine Bacteremia Model.
Mengjun Cheng,Jiaming Liang,Yufeng Zhang,Liyuan Hu,Pengjuan Gong,Ruopeng Cai,Lei Zhang,Hao Zhang,Jinli Ge,Yalu Ji,Zhimin Guo,Xin Feng,Changjiang Sun,Yongjun Yang,Liancheng Lei,Wenyu Han,Wenyu Han,Jingmin Gu +17 more
TL;DR: The isolated phage EF-P29 showed high efficiency and a broad host range against E. faecalis strains, and showed great potential as a therapeutic treatment for systemic VREF infection, indicating that phage therapies that are aimed at treating opportunistic pathogens are also feasible.
Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5
Pengjuan Gong,Mengjun Cheng,Xinwei Li,Haiyan Jiang,Chuang Yu,Nadire Kahaer,Juecheng Li,Lei Zhang,Feifei Xia,Liyuan Hu,Changjiang Sun,Xin Feng,Liancheng Lei,Wenyu Han,Jingmin Gu +14 more
TL;DR: The mutagenesis analysis revealed that the zinc ion binding residues (H27, H132, and C140), E90, and T138 are required for the catalysis of LysEFm5, and the antibacterial activity of Lys EFm5 is zinc ion independent, which is inconsistent with most of other amidase members.
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Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus
Feifei Xia,Li Xin,Bin Wang,Pengjuan Gong,Feng Xiao,Mei Yang,Lei Zhang,Jun Song,Liyuan Hu,Mengjun Cheng,Changjiang Sun,Xin Feng,Liancheng Lei,Songying Ouyang,Zhi-Jie Liu,Xinwei Li,Jingmin Gu,Wenyu Han +17 more
TL;DR: The combination therapy of LysGH15 and apigenin exhibits therapeutic potential for treating pneumonia caused by MRSA and shows the best health status, the lowest ratio of wet tissue to dry tissue of the lungs, the smallest amount of total protein and cells in the lung, the fewest pathological manifestations, and the lowest cytokine level.
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Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections.
Mengjun Cheng,Yufeng Zhang,Xinwei Li,Jiaming Liang,Liyuan Hu,Pengjuan Gong,Lei Zhang,Ruopeng Cai,Hao Zhang,Jinli Ge,Yalu Ji,Zhimin Guo,Xin Feng,Changjiang Sun,Yongjun Yang,Liancheng Lei,Wenyu Han,Wenyu Han,Jingmin Gu +18 more
TL;DR: A single administration of LysEF-P10 was sufficient to protect mice against lethal vancomycin-resistant Enterococcus faecalis (VREF) infection, and Lys EF-P 10-specific antibody did not affect its bactericidal activity or treatment effect, indicating that LysEF -P10 might be an alternative treatment for multidrug-resistant E. faecali infections.
Identification and characterization of HolGH15: the holin of Staphylococcus aureus bacteriophage GH15.
Jun Song,Feifei Xia,Haiyan Jiang,Xinwei Li,Liyuan Hu,Pengjuan Gong,Liancheng Lei,Xin Feng,Changjiang Sun,Jingmin Gu,Wenyu Han,Wenyu Han +11 more
TL;DR: To the best of the knowledge, this study is the first report of a Staphylococcus aureus phage holin that exerts antibacterial activity against heterogeneous pathogens.
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