Visible-light photoredox catalysis has been regarded as an extremely powerful tool in organic chemistry, bringing the spotlight back to radical processes. The versatility of photocatalyzed reactions has already been demonstrated to be effective in providing alternative routes for cross-coupling as well as multicomponent reactions. The photocatalyst allows the generation of high-energy intermediates through light irradiation rather than using highly reactive reagents or harsh reaction conditions. In a similar vein, organic electrochemistry has experienced a fruitful renaissance as a tool for generating reactive intermediates without the need for any catalyst. Such milder approaches pose the basis toward higher selectivity and broader applicability. In photocatalyzed and electrochemical multicomponent reactions, the generation of the radical species acts as a starter of the cascade of events. This allows for diverse reactivity and the use of reagents is usually not covered by classical methods. Owing to the availability of cheaper and more standardized photo- and electrochemical reactors, as well as easily scalable flow-setups, it is not surprising that these two fields have become areas of increased research interest. Keeping these in view, this review is aimed at providing an overview of the synthetic approaches in the design of MCRs involving photoredox catalysis and/or electrochemical activation as a crucial step with particular focus on the choice of the difunctionalized reagent.

/pdf/multicomponent-reactions-and-photo-electrochemistry-join-hzx9ufru.pdf

Multicomponent reactions and photo/electrochemistry join forces: atom economy meets energy efficiency.

Selenium, originally described as a toxin, turns out to be a crucial trace element for life that appears as selenocysteine and its dimer, selenocystine. From the point of view of drug developments, selenium-containing drugs are isosteres of sulfur and oxygen with the advantage that the presence of the selenium atom confers antioxidant properties and high lipophilicity, which would increase cell membrane permeation leading to better oral bioavailability. In this article we have focused on the relevant features of the selenium atom, above all, the corresponding synthetic approaches to access a variety of organoselenium molecules along with the proposed reaction mechanisms. The preparation and biological properties of selenosugars, including selenoglycosides, selenonucleosides, selenopeptides, and other selenium-containing compounds will be treated. We have attempted to condense the most important aspects and interesting examples of the chemistry of selenium into a single article.

Organoselenium compounds. Chemistry and applications in organic synthesis.

The recent advances on the electrochemical selenofunctionalization of unsaturated C–C bonds were comprehensively summarized in this review. 

Recent progress in the electrochemical selenofunctionalization of alkenes and alkynes

Abstract: Carbon dioxide is a harmful greenhouse gas, as well as a valuable resource. Here, a three-component cyclization reaction was developed for the synthesis of oxazolidine-2,4-diones by immobilizing CO2 under the electrochemistry and copper catalyst. Propargyl amide was used as the reaction substrate to capture carbon dioxide to produce carboxyl anion, while selenide produced electrophilic receptor to activate the triple bond under electrochemical conditions. Then, intramolecular cyclization reaction was carried out to obtain the target product. Through this environmentally friendly strategy, a series of important oxazolidine-2,4-diones was synthesized. 

Electrochemically Mediated Fixation of CO2: Synthesis of Functionalized Oxazolidine‐2,4‐Diones by Three‐Component Reactions

Organochalcogen compounds containing C−S/Se bond are motifs frequently found in various natural products, bioactive compounds, as well as functional materials. On the other hand, electrochemical organic synthesis has been regarded...

Electrochemical difunctionalization of alkenes and alkynes for the synthesis of organochalcogens involving C–S/Se bond formation

Electrochemical Radical Selenylation of Alkenes and Arenes via Se-Se Bond Activation.

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Electrochemical Radical Selenylation of Alkenes and Arenes via Se-Se Bond Activation.