7 Papers
38 Citations
Liwang Yang is an academic researcher from University of Cincinnati Academic Health Center. The author has contributed to research in topics: Exosome & Angiotensin II receptor type 1. The author has an hindex of 7, co-authored 7 publications. Previous affiliations of Liwang Yang include Shanxi Medical University & Shanxi University.
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Papers
Blockade of exosome generation with GW4869 dampens the sepsis-induced inflammation and cardiac dysfunction
Kobina Essandoh,Liwang Yang,Xiaohong Wang,Wei Huang,Dongze Qin,Jiukuan Hao,Yigang Wang,Basilia Zingarelli,Tianqing Peng,Guo-Chang Fan +9 more
TL;DR: Findings indicate that blockade of exosome generation in sepsis dampens the sepsi-triggered inflammatory response and thereby, improves cardiac function and survival.
405
Overexpression of miR-223 Tips the Balance of Pro- and Anti-hypertrophic Signaling Cascades toward Physiologic Cardiac Hypertrophy
Liwang Yang,Yutian Li,Xiaohong Wang,Xingjiang Mu,Dongze Qin,Dongze Qin,Wei Huang,Saeed Alshahrani,Michelle L. Nieman,Jiangtong Peng,Kobina Essandoh,Tianqing Peng,Yigang Wang,John N. Lorenz,Manoocher Soleimani,Zhi-Qing Zhao,Guo-Chang Fan +16 more
TL;DR: The results showed that elevation of miR-223 caused physiological cardiac hypertrophy with enhanced cardiac function but no fibrosis, and suggested that the ultimate phenotype outcome of a miRNA may be decided by the secondary net effects of the whole target network rather than by several primary direct targets in an organ/tissue.
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Edaravone inhibits pressure overload-induced cardiac fibrosis and dysfunction by reducing expression of angiotensin II AT1 receptor.
Wei-Wei Zhang,Feng Bai,Jing Wang,Rong-Hua Zheng,Liwang Yang,Erskine A. James,Zhi-Qing Zhao,Zhi-Qing Zhao +7 more
TL;DR: Taken together, edaravone treatment ameliorates cardiac fibrosis and improves left ventricular function in the pressure overload rat model, potentially via suppressing the AT1 receptor-mediated signaling pathways.
MicroRNA-223-5p and -3p Cooperatively Suppress Necroptosis in Ischemic/Reperfused Hearts
Dongze Qin,Xiaohong Wang,Yutian Li,Liwang Yang,Rui-Tao Wang,Jiangtong Peng,Kobina Essandoh,Xingjiang Mu,Tianqing Peng,Qinghua Han,Kai-Jiang Yu,Guo-Chang Fan +11 more
TL;DR: Findings indicate that miR-223-5p/-3p duplex works together and cooperatively inhibits I/R-induced cardiac necroptosis at multiple layers, and may constitute a new therapeutic agent for the treatment of ischemic heart disease.
Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice
Xiaohong Wang,Haitao Gu,Wei Huang,Jiangtong Peng,Yutian Li,Liwang Yang,Dongze Qin,Kobina Essandoh,Yigang Wang,Tianqing Peng,Guo-Chang Fan +10 more
TL;DR: The results indicate that elevation of Hsp20 in cardiomyocytes can offer protection in diabetic hearts through the release of instrumental exosomes, which might be a novel therapeutic agent for diabeticCardiomyopathy.