Liuliu Yang
Chinese Academy of Sciences
33 Papers
21 Citations
Liuliu Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 14, co-authored 24 publications. Previous affiliations of Liuliu Yang include Cornell University.
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Papers
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Liuliu Yang,Yuling Han,Benjamin E. Nilsson-Payant,Vikas Gupta,Pengfei Wang,Xiaohua Duan,Xiaohua Duan,Xuming Tang,Jiajun Zhu,Zeping Zhao,Fabrice Jaffré,Tuo Zhang,Tae Wan Kim,Oliver Harschnitz,David Redmond,Sean Houghton,Chengyang Liu,Ali Naji,Gabriele Ciceri,Sudha R Guttikonda,Yaron Bram,Duc-Huy T. Nguyen,Michele Cioffi,Vasuretha Chandar,Daisy A. Hoagland,Yaoxing Huang,Jenny Xiang,Hui Wang,Hui Wang,David Lyden,Alain C. Borczuk,Huanhuan Joyce Chen,Lorenz Studer,Fong Cheng Pan,David D. Ho,Benjamin R. tenOever,Todd Evans,Robert E. Schwartz,Shuibing Chen +38 more
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
654
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Yuling Han,Xiaohua Duan,Xiaohua Duan,Liuliu Yang,Benjamin E. Nilsson-Payant,Pengfei Wang,Fuyu Duan,Xuming Tang,Tomer M. Yaron,Tuo Zhang,Skyler Uhl,Yaron Bram,Chanel Richardson,Jiajun Zhu,Zeping Zhao,David Redmond,Sean Houghton,Duc-Huy T. Nguyen,Dong Xu,Xing Wang,Jose Jessurun,Alain C. Borczuk,Yaoxing Huang,Jared L. Johnson,Yuru Liu,Jenny Xiang,Hui Wang,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Fong Cheng Pan,Todd Evans,Huanhuan Joyce Chen,Huanhuan Joyce Chen,Robert E. Schwartz,Shuibing Chen +35 more
TL;DR: This work developed a lung organoid model using human pluripotent stem cells (hPSC-LOs) and performed a high-throughput screen of drugs approved by the FDA and identified entry inhibitors of SARS-CoV-2, including imatinib, mycophenolic acid and quinacrine dihydrochloride.
Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression
Benyu Liu,Buqing Ye,Liuliu Yang,Xiaoxiao Zhu,Guanling Huang,Pingping Zhu,Ying Du,Jiayi Wu,Xiwen Qin,Runsheng Chen,Yong Tian,Zusen Fan +11 more
TL;DR: It is observed that a divergent long noncoding RNA (lncRNA), lncKdm2b, was expressed at high levels in intestinal group 3 ILCs (ILC3s).
204
IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3.
Pingping Zhu,Xiaoxiao Zhu,Jiayi Wu,L.L. He,Tiankun Lu,Yanying Wang,Benyu Liu,Buqing Ye,Lei Sun,Dongdong Fan,Jing Wang,Liuliu Yang,Xiwen Qin,Ying Du,Chong Li,Lei He,Weizheng Ren,Xin Wu,Yong Tian,Zusen Fan +19 more
TL;DR: It is found that mouse and human Lgr5+ ISCs showed high expression of the immune cell–associated circular RNA circPan3 (originating from the Pan3 gene transcript) and, thus, the renewal of those cells in response to IL-13 derived from group 2 innate lymphoid cells.
185
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids
Yuling Han,Liuliu Yang,Xiaohua Duan,Fuyu Duan,Benjamin E. Nilsson-Payant,Tomer M. Yaron,Pengfei Wang,Xuming Tang,Tuo Zhang,Zeping Zhao,Yaron Bram,David Redmond,Sean Houghton,Duc T. Nguyen,Dong Xu,Xing Wang,Skyler Uhl,Yaoxing Huang,Jared L. Johnson,Jenny Xiang,Hui Wang,Fong Cheng Pan,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Todd Evans,Robert E. Schwartz,Huanhuan Joyce Chen,Shuibing Chen +28 more
TL;DR: It is demonstrated that hPSC-derived lung cells infected by SARS-CoV-2 can model human COVID-19 disease and provide a valuable resource to screen for FDA-approved drugs that might be repurposed and should be considered for CO VID-19 clinical trials.
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