Liu Yang
Shanghai Jiao Tong University
5 Papers
6 Citations
Liu Yang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Thyroid & Compound heterozygosity. The author has an hindex of 1, co-authored 5 publications.
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Papers
The genetic characteristics of congenital hypothyroidism in China by comprehensive screening of 21 candidate genes.
Feng Sun,Jun-Xiu Zhang,Chang-Yi Yang,Guan-Qi Gao,Wen-Bin Zhu,Bing Han,Lele Zhang,Yue-Yue Wan,Xiao-Ping Ye,Yu-Ru Ma,Man-Man Zhang,Liu Yang,Qian-Yue Zhang,Wei Liu,Cui-Cui Guo,gang Chen,Shuang-Xia Zhao,Ke-Yi Song,Huai-Dong Song +18 more
TL;DR: Most cases of congenital hypothyroidism in China were caused by thyroid dyshormonogenesis rather than thyroid dysgenesis, and DUOX2 was the most frequently mutated gene in these patients, which was significantly different from Western countries.
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Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis.
Ruimeng Yang,Ming Zhan,Qin-Yi Zhou,Xiao-Ping Ye,Feng-Yao Wu,Mei Dong,Feng Sun,Ya Fang,Rui-Jia Zhang,Chang-Run Zhang,Liu Yang,Miaomiao Guo,Jun-Xiu Zhang,Jun Liang,Feng Cheng,Wei Liu,Bing Han,Yi Zhou,Shuang-Xia Zhao,Huai-Dong Song +19 more
TL;DR: In this paper, four pathogenic GBP1 variations from three patients were identified and the functions of the identified variants were confirmed using thyroid epithelial cells in vitro and in zebrafish model organisms in vivo.
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Novel Compound Heterozygous Pathogenic Mutations of SLC5A5 in a Chinese Patient With Congenital Hypothyroidism.
Cao-Xu Zhang,Jun-Xiu Zhang,Liu Yang,Chang-Run Zhang,Feng Cheng,Rui-Jia Zhang,Ya Fang,Zheng Wang,Feng-Yao Wu,Pei-Zhang Li,Jun Liang,Rui Li,Huai-Dong Song +12 more
TL;DR: Wang et al. as discussed by the authors investigated the expression and cellular localization of the novel compound heterozygous mutation in SLC5A5, which resulted in a truncated NIS and reduced protein expression, respectively.
A five-gene panel refines differential diagnosis of thyroid nodules.
Sang-Yu Lu,Yingchao Chen,Chen-Fang Zhu,Jing Chen,Qin-Yi Zhou,Man-Man Zhang,Qian-Yue Zhang,Meng Lu,Liu Yang,Jing Wu,Shuang-Xia Zhao,Huai-Dong Song,Xiao-Ping Ye +12 more
TL;DR: Wang et al. as mentioned in this paper designed a five-gene panel including BRAF/NRAS/KRAS/HRAS/TERT genes and conducted a retrospective study to evaluate the role of this fivegene diagnostic panel in differential diagnosis of thyroid nodules.
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Three-dimensional microscopy and image fusion reconstruction analysis of the thyroid gland during morphogenesis.
TL;DR: In this article, the effects of an FGF pathway inhibitor on thyroid development were determined to be time-point-dependent and showed that the thyroid glands underwent significant transformation at critical time points.
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