The invention discloses application of acetic acid and a salt thereof Acetic acid and the salt thereof can be applied to preparation of medicines for preventing or treating ethanol induced gastric mucosal lesion, and the salt is a pharmaceutically acceptable salt Acetic acid can be used for activating the specific acceptor GPR43 of acetic acid and inhibiting inflammation reaction, and the signal path is the key of anti-inflammation and anti-oxidation of acetic acid Acetic acid serving as a histone deacetylase inhibitor (HDACi) can be used for regulating gene expression, inhibiting inflammation reaction, and promoting expression of MUC5AC and IL-10 by GPR43 or by inhibiting HDAC so as to enhance mucosal defense and reduce inflammation and oxidative damage Acetic acid can be used for reducing ethanol induced gastric mucosal lesion by resisting inflammation and oxidation and promoting expression of MUC5AC

Application of acetic acid and salt thereof

The invention provides an application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19. The butyric acid compounds are selected from at least one of butyric acid, butyrate and butyric acid derivatives. The effective concentration and the effective dose of the butyric acid compounds are 5-200 mM and 0.5-20 mmol/kg/d, respectively. For the first time, the invention finds that butyric acid compounds can be used as a specific inhibitor of long-chain non-coding RNA-H19, and can effectively inhibit abnormally elevated H19 in diseases. In a carbon tetrachloride model and a bile duct ligation model, the expression level of H19 is dozens of times higher than that in a normal group; after intervention with butyric acid compounds, the expression level of H19 is significantly reduced; and the butyric acid compounds are very effective in preventing the occurrence and development of diseases, and can effectively prevent and treat tissue and organ damage, fibrosis, canceration and many diseases due to various causes.

Application of butyric acid compounds in inhibiting long-chain non-coding RNA-H19

The invention relates to application of clostridium butylicum, in particular to application of a clostridium butylicum preparation in medicine for treating Parkinson's disease and belongs to the fieldof biological pharmacy. A brain-intestine axis is a double-way communication system based on the intestine and the brain and is composed of neuroendocrine, immune and vagus nerves, probiotics can adjust the intestinal flora, and the brain-intestine axis is adjusted and controlled to influence neural behaviors. The medicine which is good in therapeutic effect, has no toxic or side effect and is used for treating Parkinson's disease is prepared, and it is proved through animal experiments that a bacillus amylobacter preparation can have the function of Parkinson's disease prevention and have high practical value.

Anti-Parkinson's disease medicine preparation method based on brain-intestine axis and application thereof

Provided is a use of Butyribacter intestini in preventing and/or treating inflammation-related diseases. Specifically, in the present disclosure, it was firstly discovered that Butyribacter intestini has the function of preventing and/or treating inflammation-related diseases (for example, inflammatory bowel disease, such as ulcerative colitis, gastritis, and common enteritis; and rheumatoid arthritis).

Use of butyribacter intestini in preventing and/or treating inflammation-related diseases

The invention relates to the technical field of oxidization resistance, in particular to application of 2-methyl substituted fatty acid in oxidization resistance, application of 2-methyl substituted fatty acid in preparation of oxidization resistance food and/or health care products and preparation of oxidization resistance drugs. According to the application of 2-methyl substituted fatty acid inoxidization resistance, caenorhabditis elegans is adopted as a model animal, juglone is adopted as an oxidizing agent, it is discovered that 2-methyl substituted fatty acid has obvious oxidization resistance biological activity, and the oxidization resistance biological activity is reflected in the way that the survival time of caenorhabditis elegans under an acute oxidative damage condition can be obviously prolonged. 2-methyl substituted fatty acid can exert the function of oxidization resistance by adjusting ROS in the body, be used for preparing the oxidization resistance food and/or health care products and also be used for preparing the drugs and the like for preventing or treating diseases caused by oxidative stress.

Application of 2-methyl substituted fatty acid in oxidization resistance

The invention discloses application of clostridium butyricum in preparation of medicines for treating and/or preventing acute liver injury, belonging to the field of medicines. According to the application, the clostridium butyricum is capable of relieving oxidative stress response in the acute liver injury by improving the activity of superoxide dismutase and catalase as well as reducing the content of malonaldehyde in the liver tissue, and can reduce the accumulation of IL-1beta, IL-6 and TNF-alpha in the liver tissue at the same time; therefore, the clostridium butyricum has functions of resisting oxidative stress and resisting inflammatory response, and is capable of effectively treating liver injury so as to restore the normal liver functions. Furthermore, the main metabolite of the clostridium butyricum is butyric acid, so that the clostridium butyricum is beneficial to the protection of the liver.

Application of clostridium butyricum in preparation of medicines for treating and/or preventing acute liver injury

The invention discloses an application of butyric acid and salts thereof in the preparation of medicines for treating or preventing gastric ulcer, and belongs to the field of medicine. According to the above application, the butyric acid and salts thereof, through anti-inflammation and antioxidation, promote the secretion of gastric mucus, upregulate the apoptin BCL2, downregulate the pro-apoptotic protein Bax, have positive curative and preventive effects on gastric ulcer injury, effectively reduce falling, defect, atrophy and bleeding of the gastric mucous membrane, and have important significance to the prevention or treatment of gastric ulcer.

Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer

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Application of clostridium butyricum in preparation of medicines for treating and/or preventing acute liver injury

Application of butyric acid and salts thereof in preparation of medicine for treating or preventing gastric ulcer