6 Papers
23 Citations
Lisa Yan is an academic researcher from University of Southern California. The author has contributed to research in topics: Immune system & Antigen. The author has an hindex of 5, co-authored 6 publications.
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Papers
Inhibition of Langerhans Cell Maturation by Human Papillomavirus Type 16: A Novel Role for the Annexin A2 Heterotetramer in Immune Suppression
Andrew W. Woodham,Adam B. Raff,Laura M. Raff,Diane M. Da Silva,Lisa Yan,Joseph G. Skeate,Michael K. Wong,Yvonne G. Lin,W. Martin Kast +8 more
TL;DR: It is demonstrated that HPV16 suppresses LC maturation through an interaction with A2t, revealing a novel role for this protein.
Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes
Lisa Yan,Diane M. Da Silva,Bhavna Verma,Andrew N. Gray,Heike E. Brand,Joseph G. Skeate,Tania B. Porras,Shreya Kanodia,Shreya Kanodia,W. Martin Kast +9 more
TL;DR: It is hypothesized that forced expression of LIGHT in prostate tumors would shift the pattern of immune cell infiltration toward an anti‐tumoral milieu, would inhibit T regulatory cells (Tregs) and would induce prostate cancer tumor associated antigen (TAA) specific T cells that would eradicate tumors.
19
T cell ignorance is bliss: T cells are not tolerized by Langerhans cells presenting human papillomavirus antigens in the absence of costimulation.
Andrew W. Woodham,Lisa Yan,Joseph G. Skeate,Daniel van der Veen,Heike E. Brand,Michael K. Wong,Diane M. Da Silva,W. Martin Kast +7 more
TL;DR: It is demonstrated that Tregs were not induced by LCs presenting only signal 1, and through a series of in vitro immunizations show that CD8+ T cells receiving signal 1+2 from LCs weeks after consistently receiving signal1 are capable of robust effector functions.
14
Functional analysis of HPV-like particle-activated Langerhans cells in vitro.
TL;DR: Methods in analyzing functional migration and induction of antigen-specific T cells after stimulation of LCs with HPV virus-like particles in vitro are described.