Liping Chen
Boston Children's Hospital
13 Papers
2 Citations
Liping Chen is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 3 publications.
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Papers
Application of Full-Spectrum Rapid Clinical Genome Sequencing Improves Diagnostic Rate and Clinical Outcomes in Critically Ill Infants in the China Neonatal Genomes Project.
Bingbing Wu,Wenqing Kang,Yingyuan Wang,Deyi Zhuang,Liping Chen,Long Li,Yajie Su,Xinnian Pan,Qiufen Wei,Zezhong Tang,Yangfang Li,Jin Gao,Rui Cheng,Wei Zhou,Zhangxing Wang,Gang Qiu,Jian Wang,Lin Yang,Ping Zhang,Xuemei Zhao,Yao Wang,Mingyu Gan,Gang Li,Renchao Liu,Qi Ni,Feifan Xiao,Kai Yan,Yun Cao,Guoping Lu,Yulan Lu,Huijun Wang,Wenhao Zhou +31 more
TL;DR: In this paper, the diagnostic and clinical utility of the trio-rapid genome sequencing in critically ill infants was evaluated in 13 member hospitals of the China Neonatal Genomes Project spanning 10 provinces.
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Diagnostic and clinical utility of next‐generation sequencing in children born with multiple congenital anomalies in the China neonatal genomes project
Huijun Wang,Feifan Xiao,Xinran Dong,Yulan Lu,Guoqiang Cheng,Lai-Shuan Wang,Wei Lu,Lin Yang,Liping Chen,Wenqing Kang,Long Li,Xinnian Pan,Qiufen Wei,Deyi Zhuang,Dongmei Chen,Zhaoqing Yin,Ling Yang,Qi Ni,Renchao Liu,Gang Li,Ping Zhang,Yanyan Qian,Xu Li,Xiaomin Peng,Yao Wang,Fang Liu,Dahui Wang,Hao Li,Chun Shen,Liling Qian,Yun Cao,Bingbing Wu,Wenhao Zhou,Wenhao Zhou +33 more
TL;DR: In this article, the authors investigated the genetic causes and characteristics of clinical outcomes in a large cohort of neonates with multiple congenital anomalies (MCAs) at birth, and showed that both CNVs and SNVs contribute to the genetic cause of MCAs, and earlier genetic assertion may lead to better clinical management for patients.
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Alteration of E2F2 Expression in Governing Endothelial Cell Senescence
Hongfei Liu,Liping Chen,Wanli Xiao,Jiankun Liu,Changkun Long,Wenxing Zhan,Cui Cui,Lin Yang,Shenghan Chen +8 more
TL;DR: It is demonstrated that E2F2 plays an indispensable role in endothelial cell senescence, and downregulated downstream target genes including CNNA2, CDK1, and FOXM1 and overexpression restored the expression of these genes.
Melatonin Protects Against Hyperoxia-Induced Apoptosis in Alveolar Epithelial type II Cells by Activating the MT2/PI3K/AKT/ETS1 Signaling Pathway
TL;DR: Melatonin prevented hyperoxia-induced apoptosis in A549 cells, and the upregulation of E26 oncogene homolog 1 (ETS1) contributed to the antiapoptotic effect of melatonin.
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Clinical Study of 30 Novel KCNQ2 Variants/Deletions in KCNQ2-Related Disorders
Tiantian Xiao,Xiang Chen,Yan Xu,Huiyao Chen,Xinran Dong,Lin Yang,Bingbing Wu,Liping Chen,Long Li,Deyi Zhuang,Dongmei Chen,Yuanfeng Zhou,Huijun Wang,Wenhao Zhou +13 more
TL;DR: In this study, patients with novel KCNQ2 variants have variable phenotypes, whereas patients with 20q13.3 deletion involving EEF1A2, KCNZ2, and CHRNA4 genes tend to have normal neurological development.