Linlin Zhen
Nanjing Medical University
17 Papers
30 Citations
Linlin Zhen is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 10 publications.
Chat about Author
Papers
MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1
Lin Wang,Cheng-Fei Jiang,Dong-Mei Li,Xin Ge,Zhumei Shi,Chongyong Li,Xue Liu,Yu Yin,Linlin Zhen,Ling-Zhi Liu,Bing-Hua Jiang +10 more
TL;DR: Lower miR-497 levels in human CRC tissues induce KSR1 expression which is associated with CRC cancer occurrence, advanced stages, metastasis and chemoresistance, and may be a potential biomarker for CRC advanced stages and treatment response.
Estrogen regulates miRNA expression: implication of estrogen receptor and miR-124/AKT2 in tumor growth and angiogenesis
Cheng-Fei Jiang,Dong-Mei Li,Zhumei Shi,Lin Wang,Min-Min Liu,Xin Ge,Xue Liu,Ying-Chen Qian,Yi-Yang Wen,Linlin Zhen,Jie Lin,Ling-Zhi Liu,Bing-Hua Jiang +12 more
TL;DR: The results provide a mechanistic insight into a functional role of new ERα/miR-124/AKT2 signaling pathway in BC development and may be used as biomarkers for ERα positive BC and therapeutic effect in the future.
Neoadjuvant pyrotinib, trastuzumab, and docetaxel for HER2-positive breast cancer (PHEDRA): a double-blind, randomized phase 3 trial
Jiong Wu,Zefei Jiang,Zhenzhen Liu,Ben Long Yang,Hongjian Yang,Jinhai Tang,Kun Wang,Yunjiang Liu,Haibo Wang,Peifen Fu,Shuqun Zhang,Qiang Liu,Shusen Wang,Jian Huang,Chuan-Cheng Wang,Shui Wang,Yongsheng Wang,Linlin Zhen,Xiaoyu Zhu,F. Wu,Xiang Lin,Jianjun Zou +21 more
TL;DR: In this paper , pyrotinib was added to trastuzumab and docetaxel in the neoadjuvant setting to improve the total pathological complete response (tpCR) rate for HER2-positive metastatic breast cancer.
Paeoniflorin influences breast cancer cell proliferation and invasion via inhibition of the Notch‑1 signaling pathway
TL;DR: Paeoniflorin may inhibit the proliferation and invasiveness of breast cancer cells via inhibition of the NOTCH‑1 signaling pathway.
Role and mechanism of miR-222 in arsenic-transformed cells for inducing tumor growth
Min Wang,Xin Ge,Jitai Zheng,Dong-Mei Li,Xue Liu,Lin Wang,Cheng-Fei Jiang,Zhumei Shi,Lianju Qin,Jiayin Liu,Hushan Yang,Ling-Zhi Liu,Jun He,Linlin Zhen,Bing-Hua Jiang,Bing-Hua Jiang +15 more
TL;DR: It is found that miR-222 was upregulated in arsenic-transformed human lung epithelial BEAS-2B cells (As-T cells) and inhibited the expression of its direct targets ARID1A and phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and activated apoptosis of As- T cells in part through ARIDs1A downregulation.