Lingyan Wang
Dalian University of Technology
13 Papers
10 Citations
Lingyan Wang is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Cancer & Chemistry. The author has an hindex of 3, co-authored 8 publications.
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Papers
Resistance to bortezomib in breast cancer cells that downregulate Bim through FOXA1 O-GlcNAcylation
Yubo Liu,Xue Wang,Tong Zhu,Nana Zhang,Lingyan Wang,Tianmiao Huang,Yu Cao,Wenli Li,Jianing Zhang +8 more
TL;DR: The results have revealed a new regulatory mechanism that involves O‐GlcNAc elevation mediated Bim deficiency, which plays a key role in the apoptotic dysregulation and BTZ resistance in breast cancer cells.
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O-GlcNAcylation promotes the migratory ability of hepatocellular carcinoma cells via regulating FOXA2 stability and transcriptional activity.
Huang Huang,Qiong Wu,Xinyi Guo,Tianmiao Huang,Xueqin Xie,Lingyan Wang,Yangzhi Liu,Lin Shi,Wenli Li,Jianing Zhang,Yubo Liu +10 more
TL;DR: In this article, the authors demonstrated that forkhead box protein A2 (FOXA2), an essential transcription factor for liver homeostasis and HCC developing, was modified by O-GlcNAcylation and activated the ubiquitination degradation of FOXA2 in highly metastatic HCC cells.
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O-GlcNAc modification regulates MTA1 transcriptional activity during breast cancer cell genotoxic adaptation.
Xueqin Xie,Qiutong Wu,Keren Zhang,Yimin Liu,Nana Zhang,Qiushi Chen,Lingyan Wang,Wenli Li,Jianing Zhang,Yubo Liu +9 more
TL;DR: In this paper, the role of metastasis-associated protein 1 (MTA1) and its O-GlcNAc modification in breast cancer cell genotoxic adaptation was investigated through quantitative proteomics, chromatin immunoprecipitation followed by sequencing (ChIP-seq), transcriptome analysis, and loss and gain-of-function experiments.
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FOXA1 O-GlcNAcylation–mediated transcriptional switch governs metastasis capacity in breast cancer
Yajie Liu,Kairan Yu,Xiaotian Kong,Keren Zhang,Lingyan Wang,Ning Zhang,Qiushi Chen,Mingshan Niu,Wenli Li,Xiaomin Zhong,Sijin Wu,Jianing Zhang,Yubo Liu +12 more
TL;DR: It is demonstrated that the O-linked β-N-acetylglucosamine modification of FOXA1 promotes breast cancer metastasis by orchestrating the transcription of numerous metastasis regulators and indicates that targeting O-GlcNAcylation is a therapeutic strategy for metastatic breast cancer.
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Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
TL;DR: In this article, liquid chromatography-tandem mass spectrometry (LC-MS/MS) was used to identify multiple microvesicle-related sialylated proteins including CD63, a classic marker of exosomes.
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