Lingna Li
Pfizer
69 Papers
1.7K Citations
Lingna Li is an academic researcher from Pfizer. The author has contributed to research in topics: Hair follicle & Stem cell. The author has an hindex of 32, co-authored 66 publications.
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Papers
The feasibility of targeted selective gene therapy of the hair follicle.
Lingna Li,Robert M. Hoffman +1 more
TL;DR: The selective targeting of the lacZ reporter gene to the hair follicles in mice after topical application of the gene entrapped in liposomes demonstrates that highly selective, safe gene therapy for the hair process is feasible.
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Nestin-Linked Green Fluorescent Protein Transgenic Nude Mouse for Imaging Human Tumor Angiogenesis
Yasuyuki Amoh,Meng Yang,Lingna Li,Jose Reynoso,Michael Bouvet,Abdool R. Moossa,Kensei Katsuoka,Robert M. Hoffman +7 more
TL;DR: The results suggest that the ND-GFP transgenic nude mouse model is useful for the imaging of the angiogenesis of human as well as rodent tumors and visualization of the efficacy of angiogenetic inhibitors.
Whole-body and intravital optical imaging of angiogenesis in orthotopically implanted tumors.
Meng Yang,Eugene Baranov,Xiao-Ming Li,Jin Wei Wang,Ping Jiang,Lingna Li,A. R. Moossa,Sheldon Penman,Robert M. Hoffman +8 more
TL;DR: The orthotopic implantation model of human cancer has been well characterized, and fluorescence shadowing replaces the laborious histological techniques for determining blood vessel density, and these powerful and clinically relevantAngiogenesis mouse models can be used for real-time in vivo evaluation of agents inhibiting or promoting tumor angiogenesis in physiological microenvironments.
Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors.
TL;DR: Dual-color fluorescence imaging enabled visualization of human tumor–host interaction by whole-body imaging and at the cellular level in fresh and frozen tissues.
•Journal Article
Genetically fluorescent melanoma bone and organ metastasis models.
Meng Yang,Ping Jiang,Zili An,Eugene Baranov,Lingna Li,Satoshi Hasegawa,Maraya Al-Tuwaijri,Takashi Chishima,Hiroshi Shimada,A. R. Moossa,Robert M. Hoffman +10 more
TL;DR: The establishment and metastatic properties of bright, highly stable, green fluorescent protein (GFP) expression transductants of the B16 mouse malignant melanoma cell line and the LOX human melanoma line are reported to facilitate future studies of the mechanism and therapy of bone and multiorgan metastasis of melanoma.
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