Lingling Wang
University of California, San Diego
2 Papers
Lingling Wang is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Tumor microenvironment & Melanoma. The author has an hindex of 2, co-authored 2 publications.
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Papers
ALKBH5 regulates anti-PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment.
Na Li,Yuqi Kang,Lingling Wang,Sarah Huff,Rachel Tang,Hui Hui,Kriti Agrawal,Gwendolyn Gonzalez,Yinsheng Wang,Sandip Pravin Patel,Tariq M. Rana +10 more
TL;DR: It is shown that deletion of the m6A demethylase Alkbh5 sensitized tumors to cancer immunotherapy and identified ALKBH5 as a potential therapeutic target to enhance immunotherapy outcome in melanoma, colorectal, and potentially other cancers.
m 6 A RNA methyltransferases METTL3/14 regulate immune responses to anti-PD-1 therapy.
TL;DR: These findings uncover a new awareness of the function of RNA methylation in adaptive immunity and provide METTL3 and METTL14 as potential therapeutic targets in anticancer immunotherapy.
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